| http://purl.uniprot.org/citations/21220695 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21220695 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21220695 | http://www.w3.org/2000/01/rdf-schema#comment | "Selenoprotein K (Sel K) is a selenium-containing protein for which no function has been identified. We found that Sel K is an endoplasmic reticulum transmembrane protein expressed at relatively high levels in immune cells and is regulated by dietary selenium. Sel K(-/-) mice were generated and found to be similar to wild-type controls regarding growth and fertility. Immune system development was not affected by Sel K deletion, but specific immune cell defects were found in Sel K(-/-) mice. Receptor-mediated Ca(2+) flux was decreased in T cells, neutrophils, and macrophages from Sel K(-/-) mice compared with controls. Ca(2+)-dependent functions including T cell proliferation, T cell and neutrophil migration, and Fcγ receptor-mediated oxidative burst in macrophages were decreased in cells from Sel K(-/-) mice compared with that in cells from controls. West Nile virus infections were performed, and Sel K(-/-) mice exhibited decreased viral clearance in the periphery and increased viral titers in brain. Furthermore, West Nile virus-infected Sel K(-/-) mice demonstrated significantly lower survival (2 of 23; 8.7%) compared with that of wild-type controls (10 of 26; 38.5%). These results establish Sel K as an endoplasmic reticulum-membrane protein important for promoting effective Ca(2+) flux during immune cell activation and provide insight into molecular mechanisms by which dietary selenium enhances immune responses."xsd:string |
| http://purl.uniprot.org/citations/21220695 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1002878"xsd:string |
| http://purl.uniprot.org/citations/21220695 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1002878"xsd:string |
| http://purl.uniprot.org/citations/21220695 | http://purl.uniprot.org/core/author | "Huang Z."xsd:string |
| http://purl.uniprot.org/citations/21220695 | http://purl.uniprot.org/core/author | "Huang Z."xsd:string |
| http://purl.uniprot.org/citations/21220695 | http://purl.uniprot.org/core/author | "Kumar M."xsd:string |
| http://purl.uniprot.org/citations/21220695 | http://purl.uniprot.org/core/author | "Kumar M."xsd:string |
| http://purl.uniprot.org/citations/21220695 | http://purl.uniprot.org/core/author | "Verma S."xsd:string |
| http://purl.uniprot.org/citations/21220695 | http://purl.uniprot.org/core/author | "Verma S."xsd:string |
| http://purl.uniprot.org/citations/21220695 | http://purl.uniprot.org/core/author | "Hoffmann F.W."xsd:string |
| http://purl.uniprot.org/citations/21220695 | http://purl.uniprot.org/core/author | "Hoffmann F.W."xsd:string |
| http://purl.uniprot.org/citations/21220695 | http://purl.uniprot.org/core/author | "Hoffmann P.R."xsd:string |
| http://purl.uniprot.org/citations/21220695 | http://purl.uniprot.org/core/author | "Hoffmann P.R."xsd:string |
| http://purl.uniprot.org/citations/21220695 | http://purl.uniprot.org/core/author | "Roe K."xsd:string |
| http://purl.uniprot.org/citations/21220695 | http://purl.uniprot.org/core/author | "Roe K."xsd:string |
| http://purl.uniprot.org/citations/21220695 | http://purl.uniprot.org/core/author | "Hashimoto A.S."xsd:string |
| http://purl.uniprot.org/citations/21220695 | http://purl.uniprot.org/core/author | "Hashimoto A.S."xsd:string |
| http://purl.uniprot.org/citations/21220695 | http://purl.uniprot.org/core/author | "Nguyen-Wu E."xsd:string |
| http://purl.uniprot.org/citations/21220695 | http://purl.uniprot.org/core/author | "Nguyen-Wu E."xsd:string |
| http://purl.uniprot.org/citations/21220695 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21220695 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21220695 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/21220695 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |