| http://purl.uniprot.org/citations/21266579 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21266579 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21266579 | http://www.w3.org/2000/01/rdf-schema#comment | "The double-stranded RNA analog, poly(I:C), extracellularly activates both the endosomal Toll-like receptor (TLR) 3 and the cytoplasmic RNA helicase, melanoma differentiation-associated gene 5, leading to the production of type I interferons (IFNs) and inflammatory cytokines. The mechanism by which extracellular poly(I:C) is delivered to TLR3-positive organelles and the cytoplasm remains to be elucidated. Here, we show that the cytoplasmic lipid raft protein, Raftlin, is essential for poly(I:C) cellular uptake in human myeloid dendritic cells and epithelial cells. When Raftlin was silenced, poly(I:C) failed to enter cells and induction of IFN-β production was inhibited. In addition, cellular uptake of B-type oligodeoxynucleotide that shares its uptake receptor with poly(I:C) was suppressed in Raftlin knockdown cells. Upon poly(I:C) stimulation, Raftlin was translocated from the cytoplasm to the plasma membrane where it colocalized with poly(I:C), and thereafter moved to TLR3-positive endosomes. Thus, Raftlin cooperates with the uptake receptor to mediate cell entry of poly(I:C), which is critical for activation of TLR3."xsd:string |
| http://purl.uniprot.org/citations/21266579 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m110.185793"xsd:string |
| http://purl.uniprot.org/citations/21266579 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m110.185793"xsd:string |
| http://purl.uniprot.org/citations/21266579 | http://purl.uniprot.org/core/author | "Matsumoto M."xsd:string |
| http://purl.uniprot.org/citations/21266579 | http://purl.uniprot.org/core/author | "Matsumoto M."xsd:string |
| http://purl.uniprot.org/citations/21266579 | http://purl.uniprot.org/core/author | "Shibata S."xsd:string |
| http://purl.uniprot.org/citations/21266579 | http://purl.uniprot.org/core/author | "Shibata S."xsd:string |
| http://purl.uniprot.org/citations/21266579 | http://purl.uniprot.org/core/author | "Watanabe A."xsd:string |
| http://purl.uniprot.org/citations/21266579 | http://purl.uniprot.org/core/author | "Watanabe A."xsd:string |
| http://purl.uniprot.org/citations/21266579 | http://purl.uniprot.org/core/author | "Saeki K."xsd:string |
| http://purl.uniprot.org/citations/21266579 | http://purl.uniprot.org/core/author | "Saeki K."xsd:string |
| http://purl.uniprot.org/citations/21266579 | http://purl.uniprot.org/core/author | "Tatematsu M."xsd:string |
| http://purl.uniprot.org/citations/21266579 | http://purl.uniprot.org/core/author | "Tatematsu M."xsd:string |
| http://purl.uniprot.org/citations/21266579 | http://purl.uniprot.org/core/author | "Obuse C."xsd:string |
| http://purl.uniprot.org/citations/21266579 | http://purl.uniprot.org/core/author | "Obuse C."xsd:string |
| http://purl.uniprot.org/citations/21266579 | http://purl.uniprot.org/core/author | "Yoshimura A."xsd:string |
| http://purl.uniprot.org/citations/21266579 | http://purl.uniprot.org/core/author | "Yoshimura A."xsd:string |
| http://purl.uniprot.org/citations/21266579 | http://purl.uniprot.org/core/author | "Seya T."xsd:string |
| http://purl.uniprot.org/citations/21266579 | http://purl.uniprot.org/core/author | "Seya T."xsd:string |
| http://purl.uniprot.org/citations/21266579 | http://purl.uniprot.org/core/author | "Shime H."xsd:string |
| http://purl.uniprot.org/citations/21266579 | http://purl.uniprot.org/core/author | "Shime H."xsd:string |
| http://purl.uniprot.org/citations/21266579 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21266579 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |