| http://purl.uniprot.org/citations/21321938 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21321938 | http://www.w3.org/2000/01/rdf-schema#comment | "We demonstrate for the first time that the pro-inflammatory cytokine interleukin (IL)-18 stimulates rapid and significant proliferation of SMC derived from human saphenous vein (VSMC), but not coronary artery. IL-18 also stimulates VSMC growth. Further investigations revealed that IL-18-induced VSMC proliferation was Wnt inducible secreted protein-1 (WISP1) dependent. In addition to inducing its own expression via phosphatidylinositol 3-kinase/Akt-dependent IKK/NF-κB activation, IL-18 stimulated glycogen synthase kinase 3β phosphorylation and degradation, β-catenin nuclear translocation and stabilization, T-cell factor-lymphoid enhancer binding factor (TCF-LEF) activation, and WISP1 induction. Moreover, WISP1 induced its own expression, and that of survivin and multiple matrix metalloproteinases via β-catenin/TCF-LEF interaction. WISP1 also activated AP-1, but not NF-κB, and induced matrix metalloproteinase (MMP)9 transcription in part via AP-1. Interestingly, WISP1 failed to regulate tissue inhibitors of matrix metalloproteinases (TIMP) expression. These novel findings indicate that IL-18 induces a series of signaling events that result in WISP1-mediated VSMC proliferation, survival and MMP induction that are key components of vein graft stenosis and this may be amplified by IL-18 and WISP1 autoregulation and cross-regulation."xsd:string |
| http://purl.uniprot.org/citations/21321938 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcp.22676"xsd:string |
| http://purl.uniprot.org/citations/21321938 | http://purl.uniprot.org/core/author | "Reddy V.S."xsd:string |
| http://purl.uniprot.org/citations/21321938 | http://purl.uniprot.org/core/author | "Valente A.J."xsd:string |
| http://purl.uniprot.org/citations/21321938 | http://purl.uniprot.org/core/author | "Chandrasekar B."xsd:string |
| http://purl.uniprot.org/citations/21321938 | http://purl.uniprot.org/core/author | "Delafontaine P."xsd:string |
| http://purl.uniprot.org/citations/21321938 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21321938 | http://purl.uniprot.org/core/name | "J Cell Physiol"xsd:string |
| http://purl.uniprot.org/citations/21321938 | http://purl.uniprot.org/core/pages | "3303-3315"xsd:string |
| http://purl.uniprot.org/citations/21321938 | http://purl.uniprot.org/core/title | "Interleukin-18/WNT1-inducible signaling pathway protein-1 signaling mediates human saphenous vein smooth muscle cell proliferation."xsd:string |
| http://purl.uniprot.org/citations/21321938 | http://purl.uniprot.org/core/volume | "226"xsd:string |
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