| http://purl.uniprot.org/citations/21325030 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21325030 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21325030 | http://www.w3.org/2000/01/rdf-schema#comment | "Kindlin-2 is a FERM and PH domain-containing integrin-binding protein that is emerging as an important regulator of integrin activation. How kindlin-2 functions in integrin activation, however, is not known. We report here that kindlin-2 interacts with multiple phosphoinositides, preferentially with phosphatidylinositol 3,4,5-trisphosphate. Although integrin-binding is essential for focal adhesion localization of kindlin-2, phosphoinositide-binding is not required for this process. Using biologically and clinically relevant glomerular podocytes as a model system, we show that integrin activation and dependent processes are tightly regulated by kindlin-2: depletion of kindlin-2 reduced integrin activation, matrix adhesion and fibronectin matrix deposition, whereas overexpression of kindlin-2 promoted these processes. Furthermore, we provide evidence showing that kindlin-2 is involved in phosphoinositide-3-kinase-mediated regulation of podocyte-matrix adhesion and fibronectin matrix deposition. Mechanistically, kindlin-2 promotes integrin activation and integrin-dependent processes through interacting with both integrins and phosphoinositides. TGF-β1, a mediator of progressive glomerular failure, markedly increased the level of kindlin-2 and fibronectin matrix deposition, and the latter process was reversed by depletion of kindlin-2. Our results reveal important functions of kindlin-2 in the regulation of podocyte-matrix adhesion and matrix deposition and shed new light on the mechanism whereby kindlin-2 functions in these processes."xsd:string |
| http://purl.uniprot.org/citations/21325030 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.076976"xsd:string |
| http://purl.uniprot.org/citations/21325030 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.076976"xsd:string |
| http://purl.uniprot.org/citations/21325030 | http://purl.uniprot.org/core/author | "Fukuda K."xsd:string |
| http://purl.uniprot.org/citations/21325030 | http://purl.uniprot.org/core/author | "Fukuda K."xsd:string |
| http://purl.uniprot.org/citations/21325030 | http://purl.uniprot.org/core/author | "Shi X."xsd:string |
| http://purl.uniprot.org/citations/21325030 | http://purl.uniprot.org/core/author | "Shi X."xsd:string |
| http://purl.uniprot.org/citations/21325030 | http://purl.uniprot.org/core/author | "Tu Y."xsd:string |
| http://purl.uniprot.org/citations/21325030 | http://purl.uniprot.org/core/author | "Tu Y."xsd:string |
| http://purl.uniprot.org/citations/21325030 | http://purl.uniprot.org/core/author | "Qin J."xsd:string |
| http://purl.uniprot.org/citations/21325030 | http://purl.uniprot.org/core/author | "Qin J."xsd:string |
| http://purl.uniprot.org/citations/21325030 | http://purl.uniprot.org/core/author | "Wu C."xsd:string |
| http://purl.uniprot.org/citations/21325030 | http://purl.uniprot.org/core/author | "Wu C."xsd:string |
| http://purl.uniprot.org/citations/21325030 | http://purl.uniprot.org/core/author | "Saleem M.A."xsd:string |
| http://purl.uniprot.org/citations/21325030 | http://purl.uniprot.org/core/author | "Saleem M.A."xsd:string |
| http://purl.uniprot.org/citations/21325030 | http://purl.uniprot.org/core/author | "Qu H."xsd:string |
| http://purl.uniprot.org/citations/21325030 | http://purl.uniprot.org/core/author | "Qu H."xsd:string |
| http://purl.uniprot.org/citations/21325030 | http://purl.uniprot.org/core/author | "Shattil S.J."xsd:string |
| http://purl.uniprot.org/citations/21325030 | http://purl.uniprot.org/core/author | "Shattil S.J."xsd:string |
| http://purl.uniprot.org/citations/21325030 | http://purl.uniprot.org/core/author | "Kretzler M."xsd:string |
| http://purl.uniprot.org/citations/21325030 | http://purl.uniprot.org/core/author | "Kretzler M."xsd:string |
| http://purl.uniprot.org/citations/21325030 | http://purl.uniprot.org/core/author | "Larjava H."xsd:string |
| http://purl.uniprot.org/citations/21325030 | http://purl.uniprot.org/core/author | "Larjava H."xsd:string |