| http://purl.uniprot.org/citations/21343177 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21343177 | http://www.w3.org/2000/01/rdf-schema#comment | "The mechanisms by which thymosin β 4 (Tβ(4)) regulates the inflammatory response to injury are poorly understood. Previously, we demonstrated that ectopic Tβ(4) treatment inhibits injury-induced proinflammatory cytokine and chemokine production. We have also shown that Tβ(4) suppresses TNF-α-mediated NF-κB activation. Herein, we present novel evidence that Tβ(4) directly targets the NF-κB RelA/p65 subunit. We find that enforced expression of Tβ(4) interferes with TNF-α-mediated NF-κB activation, as well as downstream IL-8 gene transcription. These activities are independent of the G-actin-binding properties of Tβ(4). Tβ(4) blocks RelA/p65 nuclear translocation and targeting to the cognate κB site in the proximal region of the IL-8 gene promoter. Tβ(4) also inhibits the sensitizing effects of its intracellular binding partners, PINCH-1 and ILK, on NF-κB activity after TNF-α stimulation. The identification of a functional regulatory role by Tβ(4) and the focal adhesion proteins PINCH-1 and ILK on NF-κB activity in this study opens a new window for scientific exploration of how Tβ(4) modulates inflammation. In addition, the results of this study serve as a foundation for developing Tβ(4) as a new anti-inflammatory therapy."xsd:string |
| http://purl.uniprot.org/citations/21343177 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.10-167940"xsd:string |
| http://purl.uniprot.org/citations/21343177 | http://purl.uniprot.org/core/author | "Qiu Y."xsd:string |
| http://purl.uniprot.org/citations/21343177 | http://purl.uniprot.org/core/author | "Qiu P."xsd:string |
| http://purl.uniprot.org/citations/21343177 | http://purl.uniprot.org/core/author | "Sosne G."xsd:string |
| http://purl.uniprot.org/citations/21343177 | http://purl.uniprot.org/core/author | "Wheater M.K."xsd:string |
| http://purl.uniprot.org/citations/21343177 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21343177 | http://purl.uniprot.org/core/name | "FASEB J"xsd:string |
| http://purl.uniprot.org/citations/21343177 | http://purl.uniprot.org/core/pages | "1815-1826"xsd:string |
| http://purl.uniprot.org/citations/21343177 | http://purl.uniprot.org/core/title | "Thymosin beta4 inhibits TNF-alpha-induced NF-kappaB activation, IL-8 expression, and the sensitizing effects by its partners PINCH-1 and ILK."xsd:string |
| http://purl.uniprot.org/citations/21343177 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/21343177 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21343177 |
| http://purl.uniprot.org/citations/21343177 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21343177 |
| http://purl.uniprot.org/uniprot/Q13418#attribution-06E29CE02CFF437A9F806F1A6B01F3CF | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21343177 |
| http://purl.uniprot.org/uniprot/P48059#attribution-06E29CE02CFF437A9F806F1A6B01F3CF | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21343177 |
| http://purl.uniprot.org/uniprot/Q04206#attribution-6B190FDDC27A92A289585A3C97C85E57 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21343177 |
| http://purl.uniprot.org/uniprot/P62328#attribution-06E29CE02CFF437A9F806F1A6B01F3CF | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21343177 |
| http://purl.uniprot.org/uniprot/P62328#attribution-6B190FDDC27A92A289585A3C97C85E57 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21343177 |