| http://purl.uniprot.org/citations/21364629 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21364629 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21364629 | http://www.w3.org/2000/01/rdf-schema#comment | "Proteins containing the late embryogenesis abundant (LEA) motif comprise a conserved family, postulated to act as cell protectors. However, their function and mechanisms of action remain unclear. Here we show that PRELI, a mammalian LEA-containing homolog of yeast Ups1p, can associate with dynamin-like GTPase Optic Atrophy-1 (OPA1) and contribute to the maintenance of mitochondrial morphology. Accordingly, PRELI can uphold mitochondrial membrane potential (ΔΨ(m)) and enhance respiratory chain (RC) function, shown by its capacity to induce complex-I/NADH dehydrogenase and ATP synthase expression, increase oxygen consumption and reduce reactive oxygen species (ROS) production. PRELI can also inhibit cell death induced by STS, TNF-α or UV irradiation. Moreover, in vitro and in vivo dominant-negative overexpression of mutant PRELI/LEA(-) (lacking the LEA motif) and transient in vitro PRELI-specific knockdown can render lymphocytes vulnerable to apoptosis, cause mouse embryo lethality and revert the resistance of lymphoma cells to induced death. Collectively, these data support the long-presumed notion of LEA protein-dependent mechanisms of cytoprotection and suggest that PRELI interacts with OPA1 to maintain mitochondria structures intact, sustain balanced ion(-)/proton(+) gradients, promote oxidative phosphorylation reactions, regulate pro- and antiapoptotic protein traffic and enable cell responses to induced death. These findings may help to understand how bioenergetics is mechanistically connected with cell survival cues."xsd:string |
| http://purl.uniprot.org/citations/21364629 | http://purl.org/dc/terms/identifier | "doi:10.1038/cddis.2009.19"xsd:string |
| http://purl.uniprot.org/citations/21364629 | http://purl.org/dc/terms/identifier | "doi:10.1038/cddis.2009.19"xsd:string |
| http://purl.uniprot.org/citations/21364629 | http://purl.uniprot.org/core/author | "Chen Z."xsd:string |
| http://purl.uniprot.org/citations/21364629 | http://purl.uniprot.org/core/author | "Chen Z."xsd:string |
| http://purl.uniprot.org/citations/21364629 | http://purl.uniprot.org/core/author | "Huang P."xsd:string |
| http://purl.uniprot.org/citations/21364629 | http://purl.uniprot.org/core/author | "Huang P."xsd:string |
| http://purl.uniprot.org/citations/21364629 | http://purl.uniprot.org/core/author | "Ma W."xsd:string |
| http://purl.uniprot.org/citations/21364629 | http://purl.uniprot.org/core/author | "Ma W."xsd:string |
| http://purl.uniprot.org/citations/21364629 | http://purl.uniprot.org/core/author | "Kroemer G."xsd:string |
| http://purl.uniprot.org/citations/21364629 | http://purl.uniprot.org/core/author | "Kroemer G."xsd:string |
| http://purl.uniprot.org/citations/21364629 | http://purl.uniprot.org/core/author | "Singh K.K."xsd:string |
| http://purl.uniprot.org/citations/21364629 | http://purl.uniprot.org/core/author | "Singh K.K."xsd:string |
| http://purl.uniprot.org/citations/21364629 | http://purl.uniprot.org/core/author | "Cande C."xsd:string |
| http://purl.uniprot.org/citations/21364629 | http://purl.uniprot.org/core/author | "Cande C."xsd:string |
| http://purl.uniprot.org/citations/21364629 | http://purl.uniprot.org/core/author | "Dunner K. Jr."xsd:string |
| http://purl.uniprot.org/citations/21364629 | http://purl.uniprot.org/core/author | "Dunner K. Jr."xsd:string |
| http://purl.uniprot.org/citations/21364629 | http://purl.uniprot.org/core/author | "Herrera-Rodriguez S."xsd:string |
| http://purl.uniprot.org/citations/21364629 | http://purl.uniprot.org/core/author | "Herrera-Rodriguez S."xsd:string |
| http://purl.uniprot.org/citations/21364629 | http://purl.uniprot.org/core/author | "Martinez-Valdez H."xsd:string |
| http://purl.uniprot.org/citations/21364629 | http://purl.uniprot.org/core/author | "Martinez-Valdez H."xsd:string |
| http://purl.uniprot.org/citations/21364629 | http://purl.uniprot.org/core/author | "McKeller M.R."xsd:string |
| http://purl.uniprot.org/citations/21364629 | http://purl.uniprot.org/core/author | "McKeller M.R."xsd:string |