| http://purl.uniprot.org/citations/21525244 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21525244 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21525244 | http://www.w3.org/2000/01/rdf-schema#comment | "TRAPP is a multisubunit tethering complex implicated in multiple vesicle trafficking steps in Saccharomyces cerevisiae and conserved throughout eukarya, including humans. Here we confirm the role of TRAPPC2L as a stable component of mammalian TRAPP and report the identification of four novel components of the complex: C4orf41, TTC-15, KIAA1012, and Bet3L. Two of the components, KIAA1012 and Bet3L, are mammalian homologues of Trs85p and Bet3p, respectively. The remaining two novel TRAPP components, C4orf41 and TTC-15, have no homologues in S. cerevisiae. With this work, human homologues of all the S. cerevisiae TRAPP proteins, with the exception of the Saccharomycotina-specific subunit Trs65p, have now been reported. Through a multidisciplinary approach, we demonstrate that the novel proteins are bona fide components of human TRAPP and implicate C4orf41 and TTC-15 (which we call TRAPPC11 and TRAPPC12, respectively) in ER-to-Golgi trafficking at a very early stage. We further present a binary interaction map for all known mammalian TRAPP components and evidence that TRAPP oligomerizes. Our data are consistent with the absence of a TRAPP I-equivalent complex in mammalian cells, suggesting that the fundamental unit of mammalian TRAPP is distinct from that characterized in S. cerevisiae."xsd:string |
| http://purl.uniprot.org/citations/21525244 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e10-11-0873"xsd:string |
| http://purl.uniprot.org/citations/21525244 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e10-11-0873"xsd:string |
| http://purl.uniprot.org/citations/21525244 | http://purl.uniprot.org/core/author | "Sacher M."xsd:string |
| http://purl.uniprot.org/citations/21525244 | http://purl.uniprot.org/core/author | "Sacher M."xsd:string |
| http://purl.uniprot.org/citations/21525244 | http://purl.uniprot.org/core/author | "Brunet S."xsd:string |
| http://purl.uniprot.org/citations/21525244 | http://purl.uniprot.org/core/author | "Brunet S."xsd:string |
| http://purl.uniprot.org/citations/21525244 | http://purl.uniprot.org/core/author | "Scrivens P.J."xsd:string |
| http://purl.uniprot.org/citations/21525244 | http://purl.uniprot.org/core/author | "Scrivens P.J."xsd:string |
| http://purl.uniprot.org/citations/21525244 | http://purl.uniprot.org/core/author | "Shahrzad N."xsd:string |
| http://purl.uniprot.org/citations/21525244 | http://purl.uniprot.org/core/author | "Shahrzad N."xsd:string |
| http://purl.uniprot.org/citations/21525244 | http://purl.uniprot.org/core/author | "Hul S."xsd:string |
| http://purl.uniprot.org/citations/21525244 | http://purl.uniprot.org/core/author | "Hul S."xsd:string |
| http://purl.uniprot.org/citations/21525244 | http://purl.uniprot.org/core/author | "Noueihed B."xsd:string |
| http://purl.uniprot.org/citations/21525244 | http://purl.uniprot.org/core/author | "Noueihed B."xsd:string |
| http://purl.uniprot.org/citations/21525244 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21525244 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21525244 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/21525244 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/21525244 | http://purl.uniprot.org/core/pages | "2083-2093"xsd:string |
| http://purl.uniprot.org/citations/21525244 | http://purl.uniprot.org/core/pages | "2083-2093"xsd:string |
| http://purl.uniprot.org/citations/21525244 | http://purl.uniprot.org/core/title | "C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking."xsd:string |
| http://purl.uniprot.org/citations/21525244 | http://purl.uniprot.org/core/title | "C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking."xsd:string |