| http://purl.uniprot.org/citations/21572421 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21572421 | http://www.w3.org/2000/01/rdf-schema#comment | "The assembly of a functional mitotic spindle is crucial for achieving successful mitosis. Aurora A kinase is one of the key regulators of mitotic events, including mitotic entry, centrosome maturation and spindle bipolarity. Caenorhabditis elegans Aurora A (AIR-1) is responsible for the assembly of γ-tubulin-independent microtubules in early embryos; however, the mechanism by which AIR-1 contributes to microtubule assembly during mitosis has been unclear. Here we show by live-cell imaging and RNA-mediated interference (RNAi)-based modulation of gene activity that AIR-1 has a crucial role in the assembly of chromatin-stimulated microtubules that is independent of the γ-tubulin complex. Surprisingly, the kinase activity of AIR-1 is dispensable for this process. Although the kinase-inactive form of AIR-1 was detected along the microtubules as well as on centrosomes, the kinase-active form of AIR-1 was restricted to centrosomes. Thus, we propose that AIR-1 has a kinase-dependent role at centrosomes and a kinase-independent role for stabilizing spindle microtubules and that coordination of these two roles is crucial for the assembly of mitotic spindles."xsd:string |
| http://purl.uniprot.org/citations/21572421 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb2242"xsd:string |
| http://purl.uniprot.org/citations/21572421 | http://purl.uniprot.org/core/author | "Iida Y."xsd:string |
| http://purl.uniprot.org/citations/21572421 | http://purl.uniprot.org/core/author | "Nagata K."xsd:string |
| http://purl.uniprot.org/citations/21572421 | http://purl.uniprot.org/core/author | "Terasawa M."xsd:string |
| http://purl.uniprot.org/citations/21572421 | http://purl.uniprot.org/core/author | "Sugimoto A."xsd:string |
| http://purl.uniprot.org/citations/21572421 | http://purl.uniprot.org/core/author | "Toya M."xsd:string |
| http://purl.uniprot.org/citations/21572421 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21572421 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/21572421 | http://purl.uniprot.org/core/pages | "708-714"xsd:string |
| http://purl.uniprot.org/citations/21572421 | http://purl.uniprot.org/core/title | "A kinase-independent role for Aurora A in the assembly of mitotic spindle microtubules in Caenorhabditis elegans embryos."xsd:string |
| http://purl.uniprot.org/citations/21572421 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/21572421 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21572421 |
| http://purl.uniprot.org/citations/21572421 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21572421 |
| http://purl.uniprot.org/uniprot/G5EDL3#attribution-14003AF83E341DD2CDB8149311568F3C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21572421 |
| http://purl.uniprot.org/uniprot/G5EDL3#attribution-2502576E662B59A6E612215F74FDD9B0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21572421 |
| http://purl.uniprot.org/uniprot/Q8WSN6#attribution-14003AF83E341DD2CDB8149311568F3C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21572421 |
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| http://purl.uniprot.org/uniprot/#_G5EDE7-mappedCitation-21572421 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21572421 |
| http://purl.uniprot.org/uniprot/#_G5EDL3-mappedCitation-21572421 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21572421 |
| http://purl.uniprot.org/uniprot/#_Q8WSN6-mappedCitation-21572421 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21572421 |
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