| http://purl.uniprot.org/citations/21576369 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21576369 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21576369 | http://www.w3.org/2000/01/rdf-schema#comment | "The nuclear factor of activated T cells (NFAT) family of transcription factors is expressed in a wide range of cell types and regulates genes involved in cell cycle, differentiation, and apoptosis. NFAT proteins share two well-conserved regions, the regulatory domain and the DNA binding domain. The N- and C-terminal ends are transactivation sites and show less sequence similarity, whereas their molecular functions remain poorly understood. Here, we identified a transcriptional repressor, interferon regulatory factor 2 binding protein 2 (IRF-2BP2), which specifically interacts with the C-terminal domain of NFAT1 among the NFAT family members. IRF-2BP2 was described as a corepressor by inhibiting both enhancer-activated and basal transcription. Gene reporter assays demonstrated that IRF-2BP2 represses the NFAT1-dependent transactivation of NFAT-responsive promoters. The ectopic expression of IRF-2BP2 in CD4 T cells resulted in decreased interleukin-2 (IL-2) and IL-4 production, supporting a repressive function of IRF-2BP2 for NFAT target genes. Furthermore, NFAT1 and IRF-2BP2 colocalized in the nucleus in activated cells, and the mutation of a newly identified nuclear localization signal in the IRF-2BP2 rendered it cytoplasmic, abolishing its repressive effect on NFAT1 activity. Collectively, our data demonstrate that IRF-2BP2 is a negative regulator of the NFAT1 transcription factor and suggest that NFAT1 repression occurs at the transcriptional level."xsd:string |
| http://purl.uniprot.org/citations/21576369 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.00974-10"xsd:string |
| http://purl.uniprot.org/citations/21576369 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.00974-10"xsd:string |
| http://purl.uniprot.org/citations/21576369 | http://purl.uniprot.org/core/author | "Carneiro F.R."xsd:string |
| http://purl.uniprot.org/citations/21576369 | http://purl.uniprot.org/core/author | "Carneiro F.R."xsd:string |
| http://purl.uniprot.org/citations/21576369 | http://purl.uniprot.org/core/author | "Mognol G.P."xsd:string |
| http://purl.uniprot.org/citations/21576369 | http://purl.uniprot.org/core/author | "Mognol G.P."xsd:string |
| http://purl.uniprot.org/citations/21576369 | http://purl.uniprot.org/core/author | "Ramalho-Oliveira R."xsd:string |
| http://purl.uniprot.org/citations/21576369 | http://purl.uniprot.org/core/author | "Ramalho-Oliveira R."xsd:string |
| http://purl.uniprot.org/citations/21576369 | http://purl.uniprot.org/core/author | "Viola J.P."xsd:string |
| http://purl.uniprot.org/citations/21576369 | http://purl.uniprot.org/core/author | "Viola J.P."xsd:string |
| http://purl.uniprot.org/citations/21576369 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21576369 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21576369 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/21576369 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/21576369 | http://purl.uniprot.org/core/pages | "2889-2901"xsd:string |
| http://purl.uniprot.org/citations/21576369 | http://purl.uniprot.org/core/pages | "2889-2901"xsd:string |
| http://purl.uniprot.org/citations/21576369 | http://purl.uniprot.org/core/title | "Interferon regulatory factor 2 binding protein 2 is a new NFAT1 partner and represses its transcriptional activity."xsd:string |
| http://purl.uniprot.org/citations/21576369 | http://purl.uniprot.org/core/title | "Interferon regulatory factor 2 binding protein 2 is a new NFAT1 partner and represses its transcriptional activity."xsd:string |
| http://purl.uniprot.org/citations/21576369 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/21576369 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/21576369 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21576369 |
| http://purl.uniprot.org/citations/21576369 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21576369 |