| http://purl.uniprot.org/citations/21602803 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21602803 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21602803 | http://www.w3.org/2000/01/rdf-schema#comment | "Glutamate acting on N-methyl-D-aspartate (NMDA) receptors induces neuronal injury following stroke, through activation of poly(ADP-ribose) polymerase-1 (PARP-1) and generation of the death molecule poly(ADP-ribose) (PAR) polymer. Here we identify Iduna, a previously undescribed NMDA receptor-induced survival protein that is neuroprotective against glutamate NMDA receptor-mediated excitotoxicity both in vitro and in vivo and against stroke through interfering with PAR polymer-induced cell death (parthanatos). Iduna's protective effects are independent and downstream of PARP-1 activity. Iduna is a PAR polymer-binding protein, and mutation at the PAR polymer binding site abolishes the PAR binding activity of Iduna and attenuates its protective actions. Iduna is protective in vivo against NMDA-induced excitotoxicity and middle cerebral artery occlusion-induced stroke in mice. To our knowledge, these results define Iduna as the first known endogenous inhibitor of parthanatos. Interfering with PAR polymer signaling could be a new therapeutic strategy for the treatment of neurologic disorders."xsd:string |
| http://purl.uniprot.org/citations/21602803 | http://purl.org/dc/terms/identifier | "doi:10.1038/nm.2387"xsd:string |
| http://purl.uniprot.org/citations/21602803 | http://purl.org/dc/terms/identifier | "doi:10.1038/nm.2387"xsd:string |
| http://purl.uniprot.org/citations/21602803 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/21602803 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/21602803 | http://purl.uniprot.org/core/author | "Andrabi S.A."xsd:string |
| http://purl.uniprot.org/citations/21602803 | http://purl.uniprot.org/core/author | "Andrabi S.A."xsd:string |
| http://purl.uniprot.org/citations/21602803 | http://purl.uniprot.org/core/author | "Dawson T.M."xsd:string |
| http://purl.uniprot.org/citations/21602803 | http://purl.uniprot.org/core/author | "Dawson T.M."xsd:string |
| http://purl.uniprot.org/citations/21602803 | http://purl.uniprot.org/core/author | "Dawson V.L."xsd:string |
| http://purl.uniprot.org/citations/21602803 | http://purl.uniprot.org/core/author | "Dawson V.L."xsd:string |
| http://purl.uniprot.org/citations/21602803 | http://purl.uniprot.org/core/author | "Haince J.F."xsd:string |
| http://purl.uniprot.org/citations/21602803 | http://purl.uniprot.org/core/author | "Haince J.F."xsd:string |
| http://purl.uniprot.org/citations/21602803 | http://purl.uniprot.org/core/author | "Kang H.C."xsd:string |
| http://purl.uniprot.org/citations/21602803 | http://purl.uniprot.org/core/author | "Kang H.C."xsd:string |
| http://purl.uniprot.org/citations/21602803 | http://purl.uniprot.org/core/author | "Poirier G.G."xsd:string |
| http://purl.uniprot.org/citations/21602803 | http://purl.uniprot.org/core/author | "Poirier G.G."xsd:string |
| http://purl.uniprot.org/citations/21602803 | http://purl.uniprot.org/core/author | "Chi Z."xsd:string |
| http://purl.uniprot.org/citations/21602803 | http://purl.uniprot.org/core/author | "Chi Z."xsd:string |
| http://purl.uniprot.org/citations/21602803 | http://purl.uniprot.org/core/author | "Lee Y.I."xsd:string |
| http://purl.uniprot.org/citations/21602803 | http://purl.uniprot.org/core/author | "Lee Y.I."xsd:string |
| http://purl.uniprot.org/citations/21602803 | http://purl.uniprot.org/core/author | "West A.B."xsd:string |
| http://purl.uniprot.org/citations/21602803 | http://purl.uniprot.org/core/author | "West A.B."xsd:string |