http://purl.uniprot.org/citations/21646796 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/21646796 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundAmong several GATA family transcription factor-associating proteins, zinc finger protein, multitype 1 (ZFPM1), at least that of murine origin, has been shown to modulate the activity of GATA-3. However, the functional role of human ZFPM1 in the immune system has not been elucidated. Therefore, we here investigated the contribution of ZFPM1 to human Th1/Th2 differentiation.MethodsThe cDNA of ZFPM1 was cloned and introduced into human cord blood CD4+ T cells by a lentiviral transduction system. Then, the expression of IL-4 and IFN-γ mRNA was determined by quantitative real-time RT-PCR. The effect of ZFPM1 on the promoter activity of IL-4 and IFN-γ in Jurkat cells was also investigated.ResultsStimulation-induced expression of IL-4 and IFN-γ in human CD4+ T cells was suppressed and enhanced, respectively, by the introduction of ZFPM1. The transcriptional activity of IL-4 was also diminished by ZFPM1, whereas that of IFN-γ was not affected.ConclusionZFPM1 that facilitates human Th1 differentiation via the downregulation of IL-4 is a potential target for the treatment of allergic diseases."xsd:string |
http://purl.uniprot.org/citations/21646796 | http://purl.org/dc/terms/identifier | "doi:10.1159/000327292"xsd:string |
http://purl.uniprot.org/citations/21646796 | http://purl.uniprot.org/core/author | "Mori A."xsd:string |
http://purl.uniprot.org/citations/21646796 | http://purl.uniprot.org/core/author | "Kitamura N."xsd:string |
http://purl.uniprot.org/citations/21646796 | http://purl.uniprot.org/core/author | "Hiroi T."xsd:string |
http://purl.uniprot.org/citations/21646796 | http://purl.uniprot.org/core/author | "Tatsumi H."xsd:string |
http://purl.uniprot.org/citations/21646796 | http://purl.uniprot.org/core/author | "Nemoto S."xsd:string |
http://purl.uniprot.org/citations/21646796 | http://purl.uniprot.org/core/author | "Kaminuma O."xsd:string |
http://purl.uniprot.org/citations/21646796 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
http://purl.uniprot.org/citations/21646796 | http://purl.uniprot.org/core/name | "Int Arch Allergy Immunol 155 Suppl"xsd:string |
http://purl.uniprot.org/citations/21646796 | http://purl.uniprot.org/core/pages | "53-56"xsd:string |
http://purl.uniprot.org/citations/21646796 | http://purl.uniprot.org/core/title | "Zinc finger protein, multitype 1, suppresses human Th2 development via downregulation of IL-4."xsd:string |
http://purl.uniprot.org/citations/21646796 | http://purl.uniprot.org/core/volume | "1"xsd:string |
http://purl.uniprot.org/citations/21646796 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21646796 |
http://purl.uniprot.org/citations/21646796 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21646796 |
http://purl.uniprot.org/uniprot/Q8IX07#attribution-5C07D4F84B2B840C75F89B2D02F07DE4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21646796 |
http://purl.uniprot.org/uniprot/Q8IX07#attribution-C1C783F1E425EF1FADDC8F4AFA6B6018 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21646796 |
http://purl.uniprot.org/uniprot/#_A0A087WWQ0-mappedCitation-21646796 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21646796 |
http://purl.uniprot.org/uniprot/#_A0A087WZP1-mappedCitation-21646796 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21646796 |
http://purl.uniprot.org/uniprot/#_D4HNR6-mappedCitation-21646796 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21646796 |
http://purl.uniprot.org/uniprot/#_A1Z2K1-mappedCitation-21646796 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21646796 |
http://purl.uniprot.org/uniprot/#_B0JFA2-mappedCitation-21646796 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21646796 |
http://purl.uniprot.org/uniprot/#_G8Z3H3-mappedCitation-21646796 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21646796 |
http://purl.uniprot.org/uniprot/#_P05112-mappedCitation-21646796 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21646796 |