| http://purl.uniprot.org/citations/21690296 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21690296 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21690296 | http://www.w3.org/2000/01/rdf-schema#comment | "The tyrosine kinase c-Abl is required for full activation of T cells, while its role in T-cell differentiation has not been characterized. We report that c-Abl deficiency skews CD4(+) T cells to type 2 helper T cell (Th2) differentiation, and c-Abl(-/-) mice are more susceptible to allergic lung inflammation. c-Abl interacts with and phosphorylates T-bet, a Th1 lineage transcription factor. c-Abl-mediated phosphorylation enhances the transcriptional activation of T-bet. Interestingly, three tyrosine residues within the T-bet DNA-binding domain are the predominant sites of phosphorylation by c-Abl. Mutation of these tyrosine residues inhibits the promoter DNA-binding activity of T-bet. c-Abl regulates Th cell differentiation in a T-bet-dependent manner because genetic deletion of T-bet in CD4(+) T cells abolishes c-Abl-deficiency-mediated enhancement of Th2 differentiation. Reintroduction of T-bet-null CD4(+) T cells with wild-type T-bet, but not its tyrosine mutant, rescues gamma interferon (IFN-γ) production and inhibits Th2 cytokine production. Therefore, c-Abl catalyzes tyrosine phosphorylation of the DNA-binding domain of T-bet to regulate CD4(+) T cell differentiation."xsd:string |
| http://purl.uniprot.org/citations/21690296 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.05383-11"xsd:string |
| http://purl.uniprot.org/citations/21690296 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.05383-11"xsd:string |
| http://purl.uniprot.org/citations/21690296 | http://purl.uniprot.org/core/author | "Chen A."xsd:string |
| http://purl.uniprot.org/citations/21690296 | http://purl.uniprot.org/core/author | "Chen A."xsd:string |
| http://purl.uniprot.org/citations/21690296 | http://purl.uniprot.org/core/author | "Gao B."xsd:string |
| http://purl.uniprot.org/citations/21690296 | http://purl.uniprot.org/core/author | "Gao B."xsd:string |
| http://purl.uniprot.org/citations/21690296 | http://purl.uniprot.org/core/author | "Zhu Z."xsd:string |
| http://purl.uniprot.org/citations/21690296 | http://purl.uniprot.org/core/author | "Zhu Z."xsd:string |
| http://purl.uniprot.org/citations/21690296 | http://purl.uniprot.org/core/author | "Fang D."xsd:string |
| http://purl.uniprot.org/citations/21690296 | http://purl.uniprot.org/core/author | "Fang D."xsd:string |
| http://purl.uniprot.org/citations/21690296 | http://purl.uniprot.org/core/author | "Lee S.M."xsd:string |
| http://purl.uniprot.org/citations/21690296 | http://purl.uniprot.org/core/author | "Lee S.M."xsd:string |
| http://purl.uniprot.org/citations/21690296 | http://purl.uniprot.org/core/author | "Shannon S."xsd:string |
| http://purl.uniprot.org/citations/21690296 | http://purl.uniprot.org/core/author | "Shannon S."xsd:string |
| http://purl.uniprot.org/citations/21690296 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21690296 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21690296 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/21690296 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/21690296 | http://purl.uniprot.org/core/pages | "3445-3456"xsd:string |
| http://purl.uniprot.org/citations/21690296 | http://purl.uniprot.org/core/pages | "3445-3456"xsd:string |
| http://purl.uniprot.org/citations/21690296 | http://purl.uniprot.org/core/title | "c-Abl-mediated tyrosine phosphorylation of the T-bet DNA-binding domain regulates CD4+ T-cell differentiation and allergic lung inflammation."xsd:string |
| http://purl.uniprot.org/citations/21690296 | http://purl.uniprot.org/core/title | "c-Abl-mediated tyrosine phosphorylation of the T-bet DNA-binding domain regulates CD4+ T-cell differentiation and allergic lung inflammation."xsd:string |