| http://purl.uniprot.org/citations/21698133 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21698133 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21698133 | http://www.w3.org/2000/01/rdf-schema#comment | "The N-Myc oncoprotein is a critical factor in neuroblastoma tumorigenesis which requires additional mechanisms converting a low-level to a high-level N-Myc expression. N-Myc protein is stabilized when phosphorylated at Serine 62 by phosphorylated ERK protein. Here we describe a novel positive feedback loop whereby N-Myc directly induced the transcription of the class III histone deacetylase SIRT1, which in turn increased N-Myc protein stability. SIRT1 binds to Myc Box I domain of N-Myc protein to form a novel transcriptional repressor complex at gene promoter of mitogen-activated protein kinase phosphatase 3 (MKP3), leading to transcriptional repression of MKP3, ERK protein phosphorylation, N-Myc protein phosphorylation at Serine 62, and N-Myc protein stabilization. Importantly, SIRT1 was up-regulated, MKP3 down-regulated, in pre-cancerous cells, and preventative treatment with the SIRT1 inhibitor Cambinol reduced tumorigenesis in TH-MYCN transgenic mice. Our data demonstrate the important roles of SIRT1 in N-Myc oncogenesis and SIRT1 inhibitors in the prevention and therapy of N-Myc-induced neuroblastoma."xsd:string |
| http://purl.uniprot.org/citations/21698133 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1002135"xsd:string |
| http://purl.uniprot.org/citations/21698133 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1002135"xsd:string |
| http://purl.uniprot.org/citations/21698133 | http://purl.uniprot.org/core/author | "Liu T."xsd:string |
| http://purl.uniprot.org/citations/21698133 | http://purl.uniprot.org/core/author | "Liu T."xsd:string |
| http://purl.uniprot.org/citations/21698133 | http://purl.uniprot.org/core/author | "Thomas W."xsd:string |
| http://purl.uniprot.org/citations/21698133 | http://purl.uniprot.org/core/author | "Thomas W."xsd:string |
| http://purl.uniprot.org/citations/21698133 | http://purl.uniprot.org/core/author | "Xu N."xsd:string |
| http://purl.uniprot.org/citations/21698133 | http://purl.uniprot.org/core/author | "Xu N."xsd:string |
| http://purl.uniprot.org/citations/21698133 | http://purl.uniprot.org/core/author | "Gherardi S."xsd:string |
| http://purl.uniprot.org/citations/21698133 | http://purl.uniprot.org/core/author | "Gherardi S."xsd:string |
| http://purl.uniprot.org/citations/21698133 | http://purl.uniprot.org/core/author | "Perini G."xsd:string |
| http://purl.uniprot.org/citations/21698133 | http://purl.uniprot.org/core/author | "Perini G."xsd:string |
| http://purl.uniprot.org/citations/21698133 | http://purl.uniprot.org/core/author | "Ling D."xsd:string |
| http://purl.uniprot.org/citations/21698133 | http://purl.uniprot.org/core/author | "Ling D."xsd:string |
| http://purl.uniprot.org/citations/21698133 | http://purl.uniprot.org/core/author | "Bedalov A."xsd:string |
| http://purl.uniprot.org/citations/21698133 | http://purl.uniprot.org/core/author | "Bedalov A."xsd:string |
| http://purl.uniprot.org/citations/21698133 | http://purl.uniprot.org/core/author | "Haber M."xsd:string |
| http://purl.uniprot.org/citations/21698133 | http://purl.uniprot.org/core/author | "Haber M."xsd:string |
| http://purl.uniprot.org/citations/21698133 | http://purl.uniprot.org/core/author | "Marshall G.M."xsd:string |
| http://purl.uniprot.org/citations/21698133 | http://purl.uniprot.org/core/author | "Marshall G.M."xsd:string |
| http://purl.uniprot.org/citations/21698133 | http://purl.uniprot.org/core/author | "Norris M.D."xsd:string |
| http://purl.uniprot.org/citations/21698133 | http://purl.uniprot.org/core/author | "Norris M.D."xsd:string |