| http://purl.uniprot.org/citations/21711453 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21711453 | http://www.w3.org/2000/01/rdf-schema#comment | "MicroRNAs-221 and -222 are highly upregulated in several solid tumors, including melanomas. We demonstrate that the proto-oncogene ETS-1, involved in the pathogenesis of cancers of different origin, is a transcriptional regulator of miR-222 by direct binding to its promoter region. Differently from 293FT cells or early stage melanomas, where unphosphorylated ETS-1 represses miR-222 transcription, in metastatic melanoma the constitutively Thr-38 phosphorylated fraction of ETS-1 induces miR-222. Despite its stepwise decreased expression along with melanoma progression, the oncogenic activity of ETS-1 relies on its RAS/RAF/ERK-dependent phosphorylation status more than on its total amount. To close the loop, we demonstrate ETS-1 as a direct target of miR-222, but not miR-221, showing the novel option of their uncoupled functions. In addition, a spatial redistribution of ETS-1 protein from the nucleus to the cytoplasm is also evidenced in advanced melanoma cells. Finally, in vivo studies confirmed the contribution of miR-222 to the increased invasive potential obtained by ETS-silencing."xsd:string |
| http://purl.uniprot.org/citations/21711453 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1755-148x.2011.00881.x"xsd:string |
| http://purl.uniprot.org/citations/21711453 | http://purl.uniprot.org/core/author | "Petrini M."xsd:string |
| http://purl.uniprot.org/citations/21711453 | http://purl.uniprot.org/core/author | "Care A."xsd:string |
| http://purl.uniprot.org/citations/21711453 | http://purl.uniprot.org/core/author | "Boe A."xsd:string |
| http://purl.uniprot.org/citations/21711453 | http://purl.uniprot.org/core/author | "Romania P."xsd:string |
| http://purl.uniprot.org/citations/21711453 | http://purl.uniprot.org/core/author | "Mattia G."xsd:string |
| http://purl.uniprot.org/citations/21711453 | http://purl.uniprot.org/core/author | "Felicetti F."xsd:string |
| http://purl.uniprot.org/citations/21711453 | http://purl.uniprot.org/core/author | "Bottero L."xsd:string |
| http://purl.uniprot.org/citations/21711453 | http://purl.uniprot.org/core/author | "Colombo M.P."xsd:string |
| http://purl.uniprot.org/citations/21711453 | http://purl.uniprot.org/core/author | "Segnalini P."xsd:string |
| http://purl.uniprot.org/citations/21711453 | http://purl.uniprot.org/core/author | "Tomasello L."xsd:string |
| http://purl.uniprot.org/citations/21711453 | http://purl.uniprot.org/core/author | "Di Virgilio A."xsd:string |
| http://purl.uniprot.org/citations/21711453 | http://purl.uniprot.org/core/author | "Errico M.C."xsd:string |
| http://purl.uniprot.org/citations/21711453 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21711453 | http://purl.uniprot.org/core/name | "Pigment Cell Melanoma Res"xsd:string |
| http://purl.uniprot.org/citations/21711453 | http://purl.uniprot.org/core/pages | "953-965"xsd:string |
| http://purl.uniprot.org/citations/21711453 | http://purl.uniprot.org/core/title | "Constitutive activation of the ETS-1-miR-222 circuitry in metastatic melanoma."xsd:string |
| http://purl.uniprot.org/citations/21711453 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/21711453 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21711453 |
| http://purl.uniprot.org/citations/21711453 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21711453 |
| http://purl.uniprot.org/uniprot/P14921#attribution-71E2D035C7928DD89B0083DD904AA2EB | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21711453 |
| http://purl.uniprot.org/uniprot/#_A8K725-mappedCitation-21711453 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21711453 |
| http://purl.uniprot.org/uniprot/#_B4DW78-mappedCitation-21711453 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21711453 |