| http://purl.uniprot.org/citations/21828274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21828274 | http://www.w3.org/2000/01/rdf-schema#comment | "Nodal signaling, mediated through SMAD transcription factors, is necessary for pluripotency maintenance and endoderm commitment. We identified a new motif, termed SMAD complex-associated (SCA), that is bound by SMAD2/3/4 and FOXH1 in human embryonic stem cells (hESCs) and derived endoderm. We demonstrate that two basic helix-loop-helix (bHLH) proteins-HEB and E2A-bind the SCA motif at regions overlapping SMAD2/3 and FOXH1. Furthermore, we show that HEB and E2A associate with SMAD2/3 and FOXH1, suggesting they form a complex at critical target regions. This association is biologically important, as E2A is critical for mesendoderm specification, gastrulation, and Nodal signal transduction in Xenopus tropicalis embryos. Taken together, E proteins are novel Nodal signaling cofactors that associate with SMAD2/3 and FOXH1 and are necessary for mesendoderm differentiation."xsd:string |
| http://purl.uniprot.org/citations/21828274 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.16800511"xsd:string |
| http://purl.uniprot.org/citations/21828274 | http://purl.uniprot.org/core/author | "Gupta R."xsd:string |
| http://purl.uniprot.org/citations/21828274 | http://purl.uniprot.org/core/author | "Yoon S.J."xsd:string |
| http://purl.uniprot.org/citations/21828274 | http://purl.uniprot.org/core/author | "Baker J.C."xsd:string |
| http://purl.uniprot.org/citations/21828274 | http://purl.uniprot.org/core/author | "Wills A.E."xsd:string |
| http://purl.uniprot.org/citations/21828274 | http://purl.uniprot.org/core/author | "Chuong E."xsd:string |
| http://purl.uniprot.org/citations/21828274 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21828274 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/21828274 | http://purl.uniprot.org/core/pages | "1654-1661"xsd:string |
| http://purl.uniprot.org/citations/21828274 | http://purl.uniprot.org/core/title | "HEB and E2A function as SMAD/FOXH1 cofactors."xsd:string |
| http://purl.uniprot.org/citations/21828274 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/21828274 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21828274 |
| http://purl.uniprot.org/citations/21828274 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21828274 |
| http://purl.uniprot.org/uniprot/O75593#attribution-5F43695501F97922F8432B233B206102 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21828274 |
| http://purl.uniprot.org/uniprot/O75593#attribution-CD98EFB2CE92C6C83EAC4078E98893BB | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21828274 |
| http://purl.uniprot.org/uniprot/O75593#attribution-E45F4F317DAB233A07103921FF6AA3A5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21828274 |
| http://purl.uniprot.org/uniprot/Q99081#attribution-1905B5BEC292C6CE2AA9E1301BDAB117 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21828274 |
| http://purl.uniprot.org/uniprot/Q99081#attribution-5F43695501F97922F8432B233B206102 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21828274 |
| http://purl.uniprot.org/uniprot/Q99081#attribution-CD98EFB2CE92C6C83EAC4078E98893BB | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21828274 |
| http://purl.uniprot.org/uniprot/P08476#attribution-CD98EFB2CE92C6C83EAC4078E98893BB | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21828274 |
| http://purl.uniprot.org/uniprot/Q15796#attribution-1905B5BEC292C6CE2AA9E1301BDAB117 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21828274 |
| http://purl.uniprot.org/uniprot/Q15796#attribution-CD98EFB2CE92C6C83EAC4078E98893BB | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21828274 |
| http://purl.uniprot.org/uniprot/Q13485#attribution-CD98EFB2CE92C6C83EAC4078E98893BB | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21828274 |