| http://purl.uniprot.org/citations/21859711 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21859711 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21859711 | http://www.w3.org/2000/01/rdf-schema#comment | "Virus-host interactions are characterized by the selection of adaptive mechanisms by which to evade pathogenic and defense mechanisms, respectively. In primary T cells infected with HIV, HIV infection up-regulates TNF-related apoptosis inducing ligand (TRAIL) and death-inducing TRAIL receptors, but blockade of TRAIL:TRAIL receptor interaction does not alter HIV-induced cell death. Instead, HIV infection results in a novel splice variant that we call TRAIL-short (TRAIL-s), which antagonizes TRAIL-R2. In HIV patients, plasma TRAIL-s concentration increases with increasing viral load and renders cells resistant to TRAIL-induced death. Knockdown of TRAIL-s abrogates this resistance. We propose that TRAIL-s is a novel adaptive mechanism of apoptosis resistance acquired by HIV-infected cells to avoid their elimination by TRAIL-dependent effector mechanism."xsd:string |
| http://purl.uniprot.org/citations/21859711 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m111.274639"xsd:string |
| http://purl.uniprot.org/citations/21859711 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m111.274639"xsd:string |
| http://purl.uniprot.org/citations/21859711 | http://purl.uniprot.org/core/author | "Kaufmann S.H."xsd:string |
| http://purl.uniprot.org/citations/21859711 | http://purl.uniprot.org/core/author | "Kaufmann S.H."xsd:string |
| http://purl.uniprot.org/citations/21859711 | http://purl.uniprot.org/core/author | "Meng X.W."xsd:string |
| http://purl.uniprot.org/citations/21859711 | http://purl.uniprot.org/core/author | "Meng X.W."xsd:string |
| http://purl.uniprot.org/citations/21859711 | http://purl.uniprot.org/core/author | "Algeciras-Schimnich A."xsd:string |
| http://purl.uniprot.org/citations/21859711 | http://purl.uniprot.org/core/author | "Algeciras-Schimnich A."xsd:string |
| http://purl.uniprot.org/citations/21859711 | http://purl.uniprot.org/core/author | "Bren G.D."xsd:string |
| http://purl.uniprot.org/citations/21859711 | http://purl.uniprot.org/core/author | "Bren G.D."xsd:string |
| http://purl.uniprot.org/citations/21859711 | http://purl.uniprot.org/core/author | "Badley A.D."xsd:string |
| http://purl.uniprot.org/citations/21859711 | http://purl.uniprot.org/core/author | "Badley A.D."xsd:string |
| http://purl.uniprot.org/citations/21859711 | http://purl.uniprot.org/core/author | "Cummins N.W."xsd:string |
| http://purl.uniprot.org/citations/21859711 | http://purl.uniprot.org/core/author | "Cummins N.W."xsd:string |
| http://purl.uniprot.org/citations/21859711 | http://purl.uniprot.org/core/author | "Natesampillai S."xsd:string |
| http://purl.uniprot.org/citations/21859711 | http://purl.uniprot.org/core/author | "Natesampillai S."xsd:string |
| http://purl.uniprot.org/citations/21859711 | http://purl.uniprot.org/core/author | "Rizza S.A."xsd:string |
| http://purl.uniprot.org/citations/21859711 | http://purl.uniprot.org/core/author | "Rizza S.A."xsd:string |
| http://purl.uniprot.org/citations/21859711 | http://purl.uniprot.org/core/author | "Sainski A.M."xsd:string |
| http://purl.uniprot.org/citations/21859711 | http://purl.uniprot.org/core/author | "Sainski A.M."xsd:string |
| http://purl.uniprot.org/citations/21859711 | http://purl.uniprot.org/core/author | "Schnepple D.J."xsd:string |
| http://purl.uniprot.org/citations/21859711 | http://purl.uniprot.org/core/author | "Schnepple D.J."xsd:string |