| http://purl.uniprot.org/citations/21864583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21864583 | http://www.w3.org/2000/01/rdf-schema#comment | "A zinc-finger protein which regulates apoptosis and cell cycle arrest 1 (Zac1) is a novel seven-zinc-finger protein that can bind a specific GC-rich DNA element and has intrinsic transactivation activity; therefore, its role as a transcription factor has been proposed. Zac1 not only promotes cell cycle arrest and apoptosis but also acts as a transcriptional cofactor for nuclear receptors and p53. In this study, we examined the functional roles of mouse Zac1 (mZac1) in HeLa cells treated with 12-O-tetradecanoylphorbol-13-acetate (PMA), a potent Activator protein 1 (AP-1) activator. At first, we found that mZac1 prolonged and enhanced PMA-induced AP-1 activity in both HeLa and HeLa/p53 shRNA cells. We further identified physical and functional interactions between mZac1 and AP-1 proteins (either c-Jun, c-Fos or both). Finally, we showed that Zac1 might function as a selective coactivator of AP-1, demonstrated by AP-1-dependent transcriptional activation of collagenase, c-Fos and p21(WAF1/Cip1) promoter activities. Identification of AP-1 as a specific target for Zac1-mediated transcriptional events not only establishes a direct link between these two pivotal regulatory proteins but also raises the possibility that Zac1 contributes to certain AP-1-dependent biological effects."xsd:string |
| http://purl.uniprot.org/citations/21864583 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbamcr.2011.08.005"xsd:string |
| http://purl.uniprot.org/citations/21864583 | http://purl.uniprot.org/core/author | "Chang Y.L."xsd:string |
| http://purl.uniprot.org/citations/21864583 | http://purl.uniprot.org/core/author | "Liu S.T."xsd:string |
| http://purl.uniprot.org/citations/21864583 | http://purl.uniprot.org/core/author | "Lin W.S."xsd:string |
| http://purl.uniprot.org/citations/21864583 | http://purl.uniprot.org/core/author | "Huang S.M."xsd:string |
| http://purl.uniprot.org/citations/21864583 | http://purl.uniprot.org/core/author | "Wang W.M."xsd:string |
| http://purl.uniprot.org/citations/21864583 | http://purl.uniprot.org/core/author | "Chen S.G."xsd:string |
| http://purl.uniprot.org/citations/21864583 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21864583 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta"xsd:string |
| http://purl.uniprot.org/citations/21864583 | http://purl.uniprot.org/core/pages | "2050-2060"xsd:string |
| http://purl.uniprot.org/citations/21864583 | http://purl.uniprot.org/core/title | "Zac1 functional interactions mediate AP-1 transcriptional activity."xsd:string |
| http://purl.uniprot.org/citations/21864583 | http://purl.uniprot.org/core/volume | "1813"xsd:string |
| http://purl.uniprot.org/citations/21864583 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21864583 |
| http://purl.uniprot.org/citations/21864583 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21864583 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWE3-mappedCitation-21864583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21864583 |
| http://purl.uniprot.org/uniprot/#_B0QZX4-mappedCitation-21864583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21864583 |
| http://purl.uniprot.org/uniprot/#_B0QZX5-mappedCitation-21864583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21864583 |
| http://purl.uniprot.org/uniprot/#_B0LAB3-mappedCitation-21864583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21864583 |
| http://purl.uniprot.org/uniprot/#_B7ZP38-mappedCitation-21864583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21864583 |
| http://purl.uniprot.org/uniprot/#_Q3UQW2-mappedCitation-21864583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21864583 |
| http://purl.uniprot.org/uniprot/#_O35745-mappedCitation-21864583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21864583 |
| http://purl.uniprot.org/uniprot/#_Q3UQR2-mappedCitation-21864583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21864583 |
| http://purl.uniprot.org/uniprot/#_Q9JLQ4-mappedCitation-21864583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21864583 |