| http://purl.uniprot.org/citations/21868609 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21868609 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21868609 | http://www.w3.org/2000/01/rdf-schema#comment | "The acquisition and maintenance of shape is critical for the normal function of most cells. Here we investigate the morphology of the pharyngeal glands of Caenorhabditis elegans. These unicellular glands have long cellular processes that extend discrete lengths through the pharyngeal musculature and terminate at ducts connected to the pharyngeal lumen. From a genetic screen we identified several mutants that affect pharyngeal gland morphology. The most severe such mutant is an allele of sma-1, which encodes a β-spectrin required for embryonic elongation, including elongation of the pharynx. In sma-1 mutants, gland projections form normally but become increasingly abnormal over time, acquiring additional branches, outgrowths, and swelling, suggestive of hypertrophy. Rather than acting in pharyngeal glands, sma-1 functions in the surrounding musculature, suggesting that pharyngeal muscles play a critical role in maintenance of gland morphology by restricting their growth, and analysis of other mutants known to affect pharyngeal muscles supports this hypothesis. We suggest that gland morphology is maintained by a balance of forces from the muscles and the glands."xsd:string |
| http://purl.uniprot.org/citations/21868609 | http://purl.org/dc/terms/identifier | "doi:10.1534/genetics.111.132449"xsd:string |
| http://purl.uniprot.org/citations/21868609 | http://purl.org/dc/terms/identifier | "doi:10.1534/genetics.111.132449"xsd:string |
| http://purl.uniprot.org/citations/21868609 | http://purl.uniprot.org/core/author | "Bastiani M."xsd:string |
| http://purl.uniprot.org/citations/21868609 | http://purl.uniprot.org/core/author | "Bastiani M."xsd:string |
| http://purl.uniprot.org/citations/21868609 | http://purl.uniprot.org/core/author | "Gaudet J."xsd:string |
| http://purl.uniprot.org/citations/21868609 | http://purl.uniprot.org/core/author | "Gaudet J."xsd:string |
| http://purl.uniprot.org/citations/21868609 | http://purl.uniprot.org/core/author | "Ghai V."xsd:string |
| http://purl.uniprot.org/citations/21868609 | http://purl.uniprot.org/core/author | "Ghai V."xsd:string |
| http://purl.uniprot.org/citations/21868609 | http://purl.uniprot.org/core/author | "Dineen A."xsd:string |
| http://purl.uniprot.org/citations/21868609 | http://purl.uniprot.org/core/author | "Dineen A."xsd:string |
| http://purl.uniprot.org/citations/21868609 | http://purl.uniprot.org/core/author | "Raharjo W.H."xsd:string |
| http://purl.uniprot.org/citations/21868609 | http://purl.uniprot.org/core/author | "Raharjo W.H."xsd:string |
| http://purl.uniprot.org/citations/21868609 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21868609 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21868609 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/21868609 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/21868609 | http://purl.uniprot.org/core/pages | "885-897"xsd:string |
| http://purl.uniprot.org/citations/21868609 | http://purl.uniprot.org/core/pages | "885-897"xsd:string |
| http://purl.uniprot.org/citations/21868609 | http://purl.uniprot.org/core/title | "Cell architecture: surrounding muscle cells shape gland cell morphology in the Caenorhabditis elegans pharynx."xsd:string |
| http://purl.uniprot.org/citations/21868609 | http://purl.uniprot.org/core/title | "Cell architecture: surrounding muscle cells shape gland cell morphology in the Caenorhabditis elegans pharynx."xsd:string |
| http://purl.uniprot.org/citations/21868609 | http://purl.uniprot.org/core/volume | "189"xsd:string |
| http://purl.uniprot.org/citations/21868609 | http://purl.uniprot.org/core/volume | "189"xsd:string |