| http://purl.uniprot.org/citations/21984612 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21984612 | http://www.w3.org/2000/01/rdf-schema#comment | "Endothelial-mesenchymal transition (EndMT) plays important roles in various physiological and pathological processes. While signals mediated by transforming growth factor (TGF)-β have been implicated in EndMT, the molecular mechanisms underlying it remain to be fully elucidated. Here, we examined the effects of TGF-β signals on the EndMT of mouse pancreatic microvascular endothelial cells (MS-1). By addition of TGF-β2, MS-1 cells underwent mesenchymal transition characterized by re-organization of actin stress fibre and increased expression of various mesenchymal markers such as α-smooth muscle actin (α-SMA) through activation of Rho signals. Whereas activation of Rho signals via TGF-β-induced non-Smad signals has been implicated in epithelial-mesenchymal transition (EMT), we found that Arhgef5, a guanine nucleotide exchange factor, is induced by Smad signals and contributes to the TGF-β2-induced α-SMA expression in MS-1 cells. We also found that TGF-β2 induces the expression of myocardin-related transcription factor-A (MRTF-A) in a Smad-dependent fashion and its nuclear accumulation in MS-1 cells and that MRTF-A is required and sufficient for TGF-β2-induced α-SMA expression. These results indicate that activation of Smad signals by TGF-β2 have dual effects on the activation of Rho signals and MRTF-A leading to the mesenchymal transition of MS-1 endothelial cells."xsd:string |
| http://purl.uniprot.org/citations/21984612 | http://purl.org/dc/terms/identifier | "doi:10.1093/jb/mvr121"xsd:string |
| http://purl.uniprot.org/citations/21984612 | http://purl.uniprot.org/core/author | "Miyazono K."xsd:string |
| http://purl.uniprot.org/citations/21984612 | http://purl.uniprot.org/core/author | "Igarashi T."xsd:string |
| http://purl.uniprot.org/citations/21984612 | http://purl.uniprot.org/core/author | "Watabe T."xsd:string |
| http://purl.uniprot.org/citations/21984612 | http://purl.uniprot.org/core/author | "Yoshimatsu Y."xsd:string |
| http://purl.uniprot.org/citations/21984612 | http://purl.uniprot.org/core/author | "Suzuki H.I."xsd:string |
| http://purl.uniprot.org/citations/21984612 | http://purl.uniprot.org/core/author | "Akatsu Y."xsd:string |
| http://purl.uniprot.org/citations/21984612 | http://purl.uniprot.org/core/author | "Mihira H."xsd:string |
| http://purl.uniprot.org/citations/21984612 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/21984612 | http://purl.uniprot.org/core/name | "J Biochem"xsd:string |
| http://purl.uniprot.org/citations/21984612 | http://purl.uniprot.org/core/pages | "145-156"xsd:string |
| http://purl.uniprot.org/citations/21984612 | http://purl.uniprot.org/core/title | "TGF-beta-induced mesenchymal transition of MS-1 endothelial cells requires Smad-dependent cooperative activation of Rho signals and MRTF-A."xsd:string |
| http://purl.uniprot.org/citations/21984612 | http://purl.uniprot.org/core/volume | "151"xsd:string |
| http://purl.uniprot.org/citations/21984612 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21984612 |
| http://purl.uniprot.org/citations/21984612 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21984612 |
| http://purl.uniprot.org/uniprot/Q8K4J6#attribution-4CEBEE3BA69C0AB1F51C7C2E022DF206 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21984612 |
| http://purl.uniprot.org/uniprot/P17125#attribution-4CEBEE3BA69C0AB1F51C7C2E022DF206 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21984612 |
| http://purl.uniprot.org/uniprot/P04202#attribution-4CEBEE3BA69C0AB1F51C7C2E022DF206 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21984612 |
| http://purl.uniprot.org/uniprot/P27090#attribution-4CEBEE3BA69C0AB1F51C7C2E022DF206 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21984612 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YXU9-mappedCitation-21984612 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21984612 |
| http://purl.uniprot.org/uniprot/#_E9Q6I6-mappedCitation-21984612 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21984612 |
| http://purl.uniprot.org/uniprot/#_A0A5F8MQ33-mappedCitation-21984612 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21984612 |
| http://purl.uniprot.org/uniprot/#_A0A668KL76-mappedCitation-21984612 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21984612 |