| http://purl.uniprot.org/citations/21998312 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21998312 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21998312 | http://www.w3.org/2000/01/rdf-schema#comment | "Cellular retinoic acid-binding protein II (CRABP-II) undergoes nuclear translocation upon binding of retinoic acid (RA). In the nucleus, CRABP-II directly binds to the nuclear receptor RAR to form a complex through which RA is "channeled" from the binding protein to the receptor. CRABP-II thus facilitates the ligation of RAR and markedly enhances its transcriptional activity. The primary sequence of CRABP-II contains three putative SUMOylation sites, centered at K45, K87, and K102. We show here that RA induces interactions of CRABP-II with the E2 SUMO ligase Ubc9 and triggers SUMOylation of the protein both in vitro and in cultured cells. Mutagenesis analyses demonstrate that K102 is the sole CRABP-II residue to be SUMOylated in response to RA. Mutation of this residue abolishes the ability of CRABP-II to undergo nuclear translocation in response RA and thus impairs CRABP-II-mediated activation of RAR. Additional observations demonstrate that apo-CRABP-II is associated with endoplasmic reticulum (ER), and that RA triggers the dissociation of CRABP-II from this location. Furthermore, we show that RA-induced dissociation of CRABP-II from the ER requires SUMOylation of K102. Hence, SUMOylation of K102 in response to RA binding is critical for dissociation of CRABP-II from ER and, consequently, for mobilization of the protein to nucleus and for its cooperation with RAR."xsd:string |
| http://purl.uniprot.org/citations/21998312 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m111.293464"xsd:string |
| http://purl.uniprot.org/citations/21998312 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m111.293464"xsd:string |
| http://purl.uniprot.org/citations/21998312 | http://purl.uniprot.org/core/author | "Xiong Y."xsd:string |
| http://purl.uniprot.org/citations/21998312 | http://purl.uniprot.org/core/author | "Xiong Y."xsd:string |
| http://purl.uniprot.org/citations/21998312 | http://purl.uniprot.org/core/author | "Majumdar A."xsd:string |
| http://purl.uniprot.org/citations/21998312 | http://purl.uniprot.org/core/author | "Majumdar A."xsd:string |
| http://purl.uniprot.org/citations/21998312 | http://purl.uniprot.org/core/author | "Noy N."xsd:string |
| http://purl.uniprot.org/citations/21998312 | http://purl.uniprot.org/core/author | "Noy N."xsd:string |
| http://purl.uniprot.org/citations/21998312 | http://purl.uniprot.org/core/author | "Petrescu A.D."xsd:string |
| http://purl.uniprot.org/citations/21998312 | http://purl.uniprot.org/core/author | "Petrescu A.D."xsd:string |
| http://purl.uniprot.org/citations/21998312 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21998312 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21998312 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/21998312 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/21998312 | http://purl.uniprot.org/core/pages | "42749-42757"xsd:string |
| http://purl.uniprot.org/citations/21998312 | http://purl.uniprot.org/core/pages | "42749-42757"xsd:string |
| http://purl.uniprot.org/citations/21998312 | http://purl.uniprot.org/core/title | "Nuclear translocation of cellular retinoic acid-binding protein II is regulated by retinoic acid-controlled SUMOylation."xsd:string |
| http://purl.uniprot.org/citations/21998312 | http://purl.uniprot.org/core/title | "Nuclear translocation of cellular retinoic acid-binding protein II is regulated by retinoic acid-controlled SUMOylation."xsd:string |
| http://purl.uniprot.org/citations/21998312 | http://purl.uniprot.org/core/volume | "286"xsd:string |
| http://purl.uniprot.org/citations/21998312 | http://purl.uniprot.org/core/volume | "286"xsd:string |
| http://purl.uniprot.org/citations/21998312 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21998312 |
| http://purl.uniprot.org/citations/21998312 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21998312 |