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http://purl.uniprot.org/citations/22039842http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/22039842http://www.w3.org/2000/01/rdf-schema#comment"

Background

We investigated the association between apolipoprotein E polymorphism and ischemic heart disease with or without type 2 diabetes in Kuwait and examined the impact of apolipoprotein E polymorphism in diabetic patients.

Methods

The present study was conducted from January 2005 to June 2006 in the Diabetic Clinic of Al-Amiri and Al-Sabah Hospitals in Kuwait City. Apolipoprotein E polymorphism was assessed in 250 subjects of which 83 were ischemic heart disease patients (41 diabetic and 42 non-diabetic) and 105 were diabetic patients without ischemic heart disease. Results were compared with 62 healthy controls. Apolipoprotein E polymorphisms were detected by polymerase chain reaction-restriction fragment length polymorphism.

Results

Apolipoprotein E3 allele was the most commonly occurring form. The frequency of apolipoprotein E4 was higher in ischemic heart disease patients with type 2 diabetes (39%) and the non-diabetic (31%) group, but lower in the diabetic (20%) and control groups (16%).

Conclusion

Apolipoprotein E4 allele may be related to the development of ischemic heart disease in patients with or without type 2 diabetes in Kuwait.  However, future studies with larger population sizes are needed to establish such relationship."xsd:string
http://purl.uniprot.org/citations/22039842http://purl.uniprot.org/core/author"Al-Majed H.T."xsd:string
http://purl.uniprot.org/citations/22039842http://purl.uniprot.org/core/author"Abdullah S.A."xsd:string
http://purl.uniprot.org/citations/22039842http://purl.uniprot.org/core/author"Al-Attar A.A."xsd:string
http://purl.uniprot.org/citations/22039842http://purl.uniprot.org/core/author"Al-Sherifi A.K."xsd:string
http://purl.uniprot.org/citations/22039842http://purl.uniprot.org/core/author"Qasem A.A."xsd:string
http://purl.uniprot.org/citations/22039842http://purl.uniprot.org/core/author"Qasem J.A."xsd:string
http://purl.uniprot.org/citations/22039842http://purl.uniprot.org/core/date"2011"xsd:gYear
http://purl.uniprot.org/citations/22039842http://purl.uniprot.org/core/name"Arch Iran Med"xsd:string
http://purl.uniprot.org/citations/22039842http://purl.uniprot.org/core/pages"385-388"xsd:string
http://purl.uniprot.org/citations/22039842http://purl.uniprot.org/core/title"Association between apolipoprotein E-polymorphism and Ischemic heart disease patients with or without type 2 diabetes mellitus: a preliminary study in Kuwait."xsd:string
http://purl.uniprot.org/citations/22039842http://purl.uniprot.org/core/volume"14"xsd:string
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