| http://purl.uniprot.org/citations/22075147 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22075147 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22075147 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent studies have shown that the Hippo-Salvador-Warts (HSW) pathway restrains tissue growth by phosphorylating and inactivating the oncoprotein Yorkie. How growth-suppressive signals are transduced upstream of Hippo remains unclear. We show that the Sterile 20 family kinase, Tao-1, directly phosphorylates T195 in the Hippo activation loop and that, like other HSW pathway genes, Tao-1 functions to restrict cell proliferation in developing imaginal epithelia. This relationship appears to be evolutionarily conserved, because mammalian Tao-1 similarly affects MST kinases. In S2 cells, Tao-1 mediates the effects of the upstream HSW components Merlin and Expanded, consistent with the idea that Tao-1 functions in tissues to regulate Hippo phosphorylation. These results demonstrate that one family of Ste20 kinases can activate another and identify Tao-1 as a component of the regulatory network controlling HSW pathway signaling, and therefore tissue growth, during development."xsd:string |
| http://purl.uniprot.org/citations/22075147 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2011.08.028"xsd:string |
| http://purl.uniprot.org/citations/22075147 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2011.08.028"xsd:string |
| http://purl.uniprot.org/citations/22075147 | http://purl.uniprot.org/core/author | "Fehon R.G."xsd:string |
| http://purl.uniprot.org/citations/22075147 | http://purl.uniprot.org/core/author | "Fehon R.G."xsd:string |
| http://purl.uniprot.org/citations/22075147 | http://purl.uniprot.org/core/author | "Vanderzalm P.J."xsd:string |
| http://purl.uniprot.org/citations/22075147 | http://purl.uniprot.org/core/author | "Vanderzalm P.J."xsd:string |
| http://purl.uniprot.org/citations/22075147 | http://purl.uniprot.org/core/author | "Boggiano J.C."xsd:string |
| http://purl.uniprot.org/citations/22075147 | http://purl.uniprot.org/core/author | "Boggiano J.C."xsd:string |
| http://purl.uniprot.org/citations/22075147 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22075147 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22075147 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/22075147 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/22075147 | http://purl.uniprot.org/core/pages | "888-895"xsd:string |
| http://purl.uniprot.org/citations/22075147 | http://purl.uniprot.org/core/pages | "888-895"xsd:string |
| http://purl.uniprot.org/citations/22075147 | http://purl.uniprot.org/core/title | "Tao-1 phosphorylates Hippo/MST kinases to regulate the Hippo-Salvador-Warts tumor suppressor pathway."xsd:string |
| http://purl.uniprot.org/citations/22075147 | http://purl.uniprot.org/core/title | "Tao-1 phosphorylates Hippo/MST kinases to regulate the Hippo-Salvador-Warts tumor suppressor pathway."xsd:string |
| http://purl.uniprot.org/citations/22075147 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/22075147 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/22075147 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22075147 |
| http://purl.uniprot.org/citations/22075147 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22075147 |
| http://purl.uniprot.org/citations/22075147 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22075147 |
| http://purl.uniprot.org/citations/22075147 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22075147 |