| http://purl.uniprot.org/citations/22084111 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22084111 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22084111 | http://www.w3.org/2000/01/rdf-schema#comment | "Specialized proteins in the plasma membrane, endoplasmic reticulum (ER), and mitochondria tightly regulate intracellular calcium. A unique mechanism called store-operated calcium entry is activated when ER calcium is depleted, serving to restore intra-ER calcium levels. An ER calcium sensor, stromal interaction molecule 1 (STIM1), translocates within the ER membrane upon store depletion to the juxtaplasma membrane domain, where it interacts with intracellular domains of a highly calcium-selective plasma membrane ion channel, Orai1. STIM1 gates Orai1, allowing calcium to enter the cytoplasm, where it repletes the ER store via calcium-ATPases pumps. Here, we performed affinity purification of Orai1 from Jurkat cells to identify partner of STIM1 (POST), a 10-transmembrane-spanning segment protein of unknown function. The protein is located in the plasma membrane and ER. POST-Orai1 binding is store depletion-independent. On store depletion, the protein binds STIM1 and moves within the ER to localize near the cell membrane. This protein, TMEM20 (POST), does not affect store-operated calcium entry but does reduce plasma membrane Ca(2+) pump activity. Store depletion promotes STIM1-POST complex binding to smooth ER and plasma membrane Ca(2+) ATPases (SERCAs and PMCAs, respectively), Na/K-ATPase, as well as to the nuclear transporters, importins-β and exportins."xsd:string |
| http://purl.uniprot.org/citations/22084111 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1117231108"xsd:string |
| http://purl.uniprot.org/citations/22084111 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1117231108"xsd:string |
| http://purl.uniprot.org/citations/22084111 | http://purl.uniprot.org/core/author | "Clapham D.E."xsd:string |
| http://purl.uniprot.org/citations/22084111 | http://purl.uniprot.org/core/author | "Clapham D.E."xsd:string |
| http://purl.uniprot.org/citations/22084111 | http://purl.uniprot.org/core/author | "Krapivinsky G."xsd:string |
| http://purl.uniprot.org/citations/22084111 | http://purl.uniprot.org/core/author | "Krapivinsky G."xsd:string |
| http://purl.uniprot.org/citations/22084111 | http://purl.uniprot.org/core/author | "Krapivinsky L."xsd:string |
| http://purl.uniprot.org/citations/22084111 | http://purl.uniprot.org/core/author | "Krapivinsky L."xsd:string |
| http://purl.uniprot.org/citations/22084111 | http://purl.uniprot.org/core/author | "Manasian Y."xsd:string |
| http://purl.uniprot.org/citations/22084111 | http://purl.uniprot.org/core/author | "Manasian Y."xsd:string |
| http://purl.uniprot.org/citations/22084111 | http://purl.uniprot.org/core/author | "Stotz S.C."xsd:string |
| http://purl.uniprot.org/citations/22084111 | http://purl.uniprot.org/core/author | "Stotz S.C."xsd:string |
| http://purl.uniprot.org/citations/22084111 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22084111 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22084111 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/22084111 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/22084111 | http://purl.uniprot.org/core/pages | "19234-19239"xsd:string |
| http://purl.uniprot.org/citations/22084111 | http://purl.uniprot.org/core/pages | "19234-19239"xsd:string |
| http://purl.uniprot.org/citations/22084111 | http://purl.uniprot.org/core/title | "POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters."xsd:string |
| http://purl.uniprot.org/citations/22084111 | http://purl.uniprot.org/core/title | "POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters."xsd:string |
| http://purl.uniprot.org/citations/22084111 | http://purl.uniprot.org/core/volume | "108"xsd:string |
| http://purl.uniprot.org/citations/22084111 | http://purl.uniprot.org/core/volume | "108"xsd:string |