| http://purl.uniprot.org/citations/22118466 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22118466 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22118466 | http://www.w3.org/2000/01/rdf-schema#comment | "SNAREs provide a large part of the specificity and energy needed for membrane fusion and, to do so, must be localized to their correct membranes. Here, we show that the R-SNAREs VAMP8, VAMP3, and VAMP2, which cycle between the plasma membrane and endosomes, bind directly to the ubiquitously expressed, PtdIns4,5P(2)-binding, endocytic clathrin adaptor CALM/PICALM. X-ray crystallography shows that the N-terminal halves of their SNARE motifs bind the CALM(ANTH) domain as helices in a manner that mimics SNARE complex formation. Mutation of residues in the CALM:SNARE interface inhibits binding in vitro and prevents R-SNARE endocytosis in vivo. Thus, CALM:R-SNARE interactions ensure that R-SNAREs, required for the fusion of endocytic clathrin-coated vesicles with endosomes and also for subsequent postendosomal trafficking, are sorted into endocytic vesicles. CALM's role in directing the endocytosis of small R-SNAREs may provide insight into the association of CALM/PICALM mutations with growth retardation, cognitive defects, and Alzheimer's disease."xsd:string |
| http://purl.uniprot.org/citations/22118466 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2011.10.038"xsd:string |
| http://purl.uniprot.org/citations/22118466 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2011.10.038"xsd:string |
| http://purl.uniprot.org/citations/22118466 | http://purl.uniprot.org/core/author | "Graham S.C."xsd:string |
| http://purl.uniprot.org/citations/22118466 | http://purl.uniprot.org/core/author | "Graham S.C."xsd:string |
| http://purl.uniprot.org/citations/22118466 | http://purl.uniprot.org/core/author | "Peden A.A."xsd:string |
| http://purl.uniprot.org/citations/22118466 | http://purl.uniprot.org/core/author | "Peden A.A."xsd:string |
| http://purl.uniprot.org/citations/22118466 | http://purl.uniprot.org/core/author | "Honing S."xsd:string |
| http://purl.uniprot.org/citations/22118466 | http://purl.uniprot.org/core/author | "Honing S."xsd:string |
| http://purl.uniprot.org/citations/22118466 | http://purl.uniprot.org/core/author | "Robinson M.S."xsd:string |
| http://purl.uniprot.org/citations/22118466 | http://purl.uniprot.org/core/author | "Robinson M.S."xsd:string |
| http://purl.uniprot.org/citations/22118466 | http://purl.uniprot.org/core/author | "Sahlender D.A."xsd:string |
| http://purl.uniprot.org/citations/22118466 | http://purl.uniprot.org/core/author | "Sahlender D.A."xsd:string |
| http://purl.uniprot.org/citations/22118466 | http://purl.uniprot.org/core/author | "Owen D.J."xsd:string |
| http://purl.uniprot.org/citations/22118466 | http://purl.uniprot.org/core/author | "Owen D.J."xsd:string |
| http://purl.uniprot.org/citations/22118466 | http://purl.uniprot.org/core/author | "Miller S.E."xsd:string |
| http://purl.uniprot.org/citations/22118466 | http://purl.uniprot.org/core/author | "Miller S.E."xsd:string |
| http://purl.uniprot.org/citations/22118466 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22118466 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22118466 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/22118466 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/22118466 | http://purl.uniprot.org/core/pages | "1118-1131"xsd:string |
| http://purl.uniprot.org/citations/22118466 | http://purl.uniprot.org/core/pages | "1118-1131"xsd:string |