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| http://purl.uniprot.org/citations/22153373 | http://www.w3.org/2000/01/rdf-schema#comment | "We provide evidence for a prodegenerative, glial-derived signaling framework in the Drosophila neuromuscular system that includes caspase and mitochondria-dependent signaling. We demonstrate that Drosophila TNF-α (eiger) is expressed in a subset of peripheral glia, and the TNF-α receptor (TNFR), Wengen, is expressed in motoneurons. NMJ degeneration caused by disruption of the spectrin/ankyrin skeleton is suppressed by an eiger mutation or by eiger knockdown within a subset of peripheral glia. Loss of wengen in motoneurons causes a similar suppression providing evidence for glial-derived prodegenerative TNF-α signaling. Neither JNK nor NFκβ is required for prodegenerative signaling. However, we provide evidence for the involvement of both an initiator and effector caspase, Dronc and Dcp-1, and mitochondrial-dependent signaling. Mutations that deplete the axon and nerve terminal of mitochondria suppress degeneration as do mutations in Drosophila Bcl-2 (debcl), a mitochondria-associated protein, and Apaf-1 (dark), which links mitochondrial signaling with caspase activity in other systems."xsd:string |
| http://purl.uniprot.org/citations/22153373 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2011.09.031"xsd:string |
| http://purl.uniprot.org/citations/22153373 | http://purl.uniprot.org/core/author | "Cheng L."xsd:string |
| http://purl.uniprot.org/citations/22153373 | http://purl.uniprot.org/core/author | "Muller M."xsd:string |
| http://purl.uniprot.org/citations/22153373 | http://purl.uniprot.org/core/author | "Keller L.C."xsd:string |
| http://purl.uniprot.org/citations/22153373 | http://purl.uniprot.org/core/author | "Fetter R.D."xsd:string |
| http://purl.uniprot.org/citations/22153373 | http://purl.uniprot.org/core/author | "Locke C.J."xsd:string |
| http://purl.uniprot.org/citations/22153373 | http://purl.uniprot.org/core/author | "Davis G.W."xsd:string |
| http://purl.uniprot.org/citations/22153373 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22153373 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/22153373 | http://purl.uniprot.org/core/pages | "760-775"xsd:string |
| http://purl.uniprot.org/citations/22153373 | http://purl.uniprot.org/core/title | "Glial-derived prodegenerative signaling in the Drosophila neuromuscular system."xsd:string |
| http://purl.uniprot.org/citations/22153373 | http://purl.uniprot.org/core/volume | "72"xsd:string |
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