| http://purl.uniprot.org/citations/22158417 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22158417 | http://www.w3.org/2000/01/rdf-schema#comment | "The family of death domain (DD)-containing proteins are involved in many cellular processes, including apoptosis, inflammation and development. One of these molecules, the adapter protein MyD88, is a key factor in innate and adaptive immunity that integrates signals from the Toll-like receptor/interleukin (IL)-1 receptor (TLR/IL-1R) superfamily by providing an activation platform for IL-1R-associated kinases (IRAKs). Here we show that the DD-containing protein Unc5CL (also known as ZUD) is involved in a novel MyD88-independent mode of IRAK signaling that culminates in the activation of the transcription factor nuclear factor kappa B (NF-κB) and c-Jun N-terminal kinase. Unc5CL required IRAK1, IRAK4 and TNF receptor-associated factor 6 but not MyD88 for its ability to activate these pathways. Interestingly, the protein is constitutively autoproteolytically processed, and is anchored by its N-terminus specifically to the apical face of mucosal epithelial cells. Transcriptional profiling identified mainly chemokines, including IL-8, CXCL1 and CCL20 as Unc5CL target genes. Its prominent expression in mucosal tissues, as well as its ability to induce a pro-inflammatory program in cells, suggests that Unc5CL is a factor in epithelial inflammation and immunity as well as a candidate gene involved in mucosal diseases such as inflammatory bowel disease."xsd:string |
| http://purl.uniprot.org/citations/22158417 | http://purl.org/dc/terms/identifier | "doi:10.1038/cdd.2011.147"xsd:string |
| http://purl.uniprot.org/citations/22158417 | http://purl.uniprot.org/core/author | "Quadroni M."xsd:string |
| http://purl.uniprot.org/citations/22158417 | http://purl.uniprot.org/core/author | "Schroder K."xsd:string |
| http://purl.uniprot.org/citations/22158417 | http://purl.uniprot.org/core/author | "Schneider P."xsd:string |
| http://purl.uniprot.org/citations/22158417 | http://purl.uniprot.org/core/author | "Tschopp J."xsd:string |
| http://purl.uniprot.org/citations/22158417 | http://purl.uniprot.org/core/author | "Gross O."xsd:string |
| http://purl.uniprot.org/citations/22158417 | http://purl.uniprot.org/core/author | "Rebsamen M."xsd:string |
| http://purl.uniprot.org/citations/22158417 | http://purl.uniprot.org/core/author | "Heinz L.X."xsd:string |
| http://purl.uniprot.org/citations/22158417 | http://purl.uniprot.org/core/author | "Rossi D.C."xsd:string |
| http://purl.uniprot.org/citations/22158417 | http://purl.uniprot.org/core/author | "Staehli F."xsd:string |
| http://purl.uniprot.org/citations/22158417 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22158417 | http://purl.uniprot.org/core/name | "Cell Death Differ"xsd:string |
| http://purl.uniprot.org/citations/22158417 | http://purl.uniprot.org/core/pages | "722-731"xsd:string |
| http://purl.uniprot.org/citations/22158417 | http://purl.uniprot.org/core/title | "The death domain-containing protein Unc5CL is a novel MyD88-independent activator of the pro-inflammatory IRAK signaling cascade."xsd:string |
| http://purl.uniprot.org/citations/22158417 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/22158417 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22158417 |
| http://purl.uniprot.org/citations/22158417 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22158417 |
| http://purl.uniprot.org/uniprot/P51617#attribution-9577DCC499022156808DB7F19089229A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22158417 |
| http://purl.uniprot.org/uniprot/Q9NWZ3#attribution-9577DCC499022156808DB7F19089229A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22158417 |
| http://purl.uniprot.org/uniprot/Q6R653#attribution-1D1B5B922E44DFDFFD13BA3DD6630356 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22158417 |
| http://purl.uniprot.org/uniprot/Q8IV45#attribution-1D1B5B922E44DFDFFD13BA3DD6630356 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22158417 |
| http://purl.uniprot.org/uniprot/Q9Y423#attribution-9577DCC499022156808DB7F19089229A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22158417 |
| http://purl.uniprot.org/uniprot/#_E0CXQ5-mappedCitation-22158417 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22158417 |