| http://purl.uniprot.org/citations/22159118 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22159118 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22159118 | http://www.w3.org/2000/01/rdf-schema#comment | "In the CNS, interleukin-1β (IL-1β) is synthesized and released during injury, infection, and disease, mediating inflammatory responses. However, IL-1β is also present in the brain under physiological conditions, and can influence hippocampal neuronal function. Several cell-specific IL-1-mediated signaling pathways and functions have been identified in neurons and astrocytes, but their mechanisms have not been fully defined. In astrocytes, IL-1β induced both the p38 MAPK and NF-κB (nuclear factor κB) pathways regulating inflammatory responses, however in hippocampal neurons IL-1β activated p38 but not NF-κB. Additionally, IL-1β induced Src phosphorylation at 0.01 ng/ml in hippocampal neurons, a dose 1000-fold lower than that used to stimulate inflammatory responses. IL-1 signaling requires the type 1 IL-1 receptor and the IL-1 receptor accessory protein (IL-1RAcP) as a receptor partner. We previously reported a novel isoform of the IL-1RAcP, IL-1RAcPb, found exclusively in CNS neurons. In this study, we demonstrate that AcPb specifically mediates IL-1β activation of p-Src and potentiation of NMDA-induced calcium influx in mouse hippocampal neurons in a dose-dependent manner. Mice lacking the AcPb, but retaining the AcP, isoform were deficient in IL-1β regulation of p-Src in neurons. AcPb also played a modulatory role in the activation of p38 MAPK, but had no effect on NF-κB signaling. The restricted expression of AcPb in CNS neurons, therefore, governs specific neuronal signaling and functional responses to IL-1β."xsd:string |
| http://purl.uniprot.org/citations/22159118 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.4067-11.2011"xsd:string |
| http://purl.uniprot.org/citations/22159118 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.4067-11.2011"xsd:string |
| http://purl.uniprot.org/citations/22159118 | http://purl.uniprot.org/core/author | "Huang Y."xsd:string |
| http://purl.uniprot.org/citations/22159118 | http://purl.uniprot.org/core/author | "Huang Y."xsd:string |
| http://purl.uniprot.org/citations/22159118 | http://purl.uniprot.org/core/author | "Smith D.E."xsd:string |
| http://purl.uniprot.org/citations/22159118 | http://purl.uniprot.org/core/author | "Smith D.E."xsd:string |
| http://purl.uniprot.org/citations/22159118 | http://purl.uniprot.org/core/author | "Sims J.E."xsd:string |
| http://purl.uniprot.org/citations/22159118 | http://purl.uniprot.org/core/author | "Sims J.E."xsd:string |
| http://purl.uniprot.org/citations/22159118 | http://purl.uniprot.org/core/author | "Friedman W.J."xsd:string |
| http://purl.uniprot.org/citations/22159118 | http://purl.uniprot.org/core/author | "Friedman W.J."xsd:string |
| http://purl.uniprot.org/citations/22159118 | http://purl.uniprot.org/core/author | "Ibanez-Sandoval O."xsd:string |
| http://purl.uniprot.org/citations/22159118 | http://purl.uniprot.org/core/author | "Ibanez-Sandoval O."xsd:string |
| http://purl.uniprot.org/citations/22159118 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22159118 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22159118 | http://purl.uniprot.org/core/name | "J. Neurosci."xsd:string |
| http://purl.uniprot.org/citations/22159118 | http://purl.uniprot.org/core/name | "J. Neurosci."xsd:string |
| http://purl.uniprot.org/citations/22159118 | http://purl.uniprot.org/core/pages | "18048-18059"xsd:string |
| http://purl.uniprot.org/citations/22159118 | http://purl.uniprot.org/core/pages | "18048-18059"xsd:string |
| http://purl.uniprot.org/citations/22159118 | http://purl.uniprot.org/core/title | "Neuron-specific effects of interleukin-1beta are mediated by a novel isoform of the IL-1 receptor accessory protein."xsd:string |
| http://purl.uniprot.org/citations/22159118 | http://purl.uniprot.org/core/title | "Neuron-specific effects of interleukin-1beta are mediated by a novel isoform of the IL-1 receptor accessory protein."xsd:string |
| http://purl.uniprot.org/citations/22159118 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/22159118 | http://purl.uniprot.org/core/volume | "31"xsd:string |