| http://purl.uniprot.org/citations/22179183 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22179183 | http://www.w3.org/2000/01/rdf-schema#comment | "Adenomatous polyposis coli (APC) is a multifunctional protein as well as a tumor suppressor. To determine the functions of the C-terminal domain of Apc, we have investigated Apc ( 1638T/1638T ) mice, which express a truncated Apc that lacks the C-terminal domain. Apc ( 1638T/1638T ) mice are tumor free and exhibit growth retardation. In the present study, we analyzed the morphology and functions of the thyroid gland in Apc ( 1638T/1638T ) mice. There was no significant difference in the basal concentration of serum thyroid hormones between Apc ( 1638T/1638T ) and Apc (+/+) mice. Thyroid follicle size was significantly larger in Apc ( 1638T/1638T ) mice than in Apc (+/+) mice. The extent of serum T4 elevation following exogenous thyroid-stimulating hormone (TSH) injection was lower in Apc ( 1638T/1638T ) mice than in Apc (+/+) mice. TSH also induced a greater reduction in thyroid follicle size in Apc ( 1638T/1638T ) mice than in Apc (+/+) mice. Analyses using immunohistochemistry and electron microscopy indicated that follicular epithelial cells in Apc ( 1638T/1638T ) mice had an enlarged rough endoplasmic reticulum of irregular shape. These results suggest that the C-terminal domain of Apc is involved in thyroid morphology and function."xsd:string |
| http://purl.uniprot.org/citations/22179183 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00795-010-0529-9"xsd:string |
| http://purl.uniprot.org/citations/22179183 | http://purl.uniprot.org/core/author | "Fodde R."xsd:string |
| http://purl.uniprot.org/citations/22179183 | http://purl.uniprot.org/core/author | "Itoh M."xsd:string |
| http://purl.uniprot.org/citations/22179183 | http://purl.uniprot.org/core/author | "Nomura R."xsd:string |
| http://purl.uniprot.org/citations/22179183 | http://purl.uniprot.org/core/author | "Senda T."xsd:string |
| http://purl.uniprot.org/citations/22179183 | http://purl.uniprot.org/core/author | "Yokoyama A."xsd:string |
| http://purl.uniprot.org/citations/22179183 | http://purl.uniprot.org/core/author | "Smits R."xsd:string |
| http://purl.uniprot.org/citations/22179183 | http://purl.uniprot.org/core/author | "Oda N."xsd:string |
| http://purl.uniprot.org/citations/22179183 | http://purl.uniprot.org/core/author | "Iizuka-Kogo A."xsd:string |
| http://purl.uniprot.org/citations/22179183 | http://purl.uniprot.org/core/author | "Onouchi T."xsd:string |
| http://purl.uniprot.org/citations/22179183 | http://purl.uniprot.org/core/author | "Shimomura A."xsd:string |
| http://purl.uniprot.org/citations/22179183 | http://purl.uniprot.org/core/author | "Kurosumi M."xsd:string |
| http://purl.uniprot.org/citations/22179183 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22179183 | http://purl.uniprot.org/core/name | "Med Mol Morphol"xsd:string |
| http://purl.uniprot.org/citations/22179183 | http://purl.uniprot.org/core/pages | "207-212"xsd:string |
| http://purl.uniprot.org/citations/22179183 | http://purl.uniprot.org/core/title | "The C-terminal domain of the adenomatous polyposis coli (Apc) protein is involved in thyroid morphogenesis and function."xsd:string |
| http://purl.uniprot.org/citations/22179183 | http://purl.uniprot.org/core/volume | "44"xsd:string |
| http://purl.uniprot.org/citations/22179183 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22179183 |
| http://purl.uniprot.org/citations/22179183 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22179183 |
| http://purl.uniprot.org/uniprot/#_B2RUG9-mappedCitation-22179183 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22179183 |
| http://purl.uniprot.org/uniprot/#_P70382-mappedCitation-22179183 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22179183 |
| http://purl.uniprot.org/uniprot/#_Q8BRD8-mappedCitation-22179183 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22179183 |
| http://purl.uniprot.org/uniprot/#_Q3UQT2-mappedCitation-22179183 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22179183 |