| http://purl.uniprot.org/citations/22215666 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22215666 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22215666 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin 33 (IL-33), a member of the Interleukin 1 cytokine family, is implicated in numerous human inflammatory diseases such as asthma, atherosclerosis, and rheumatoid arthritis. Despite its pathophysiologic importance, fundamental questions regarding the basic biology of IL-33 remain. Nuclear localization and lack of an export signal sequence are consistent with the view of IL-33 as a nuclear factor with the ability to repress RNA transcription. However, signaling via the transmembrane receptor ST2 and documented caspase-dependent inactivation have suggested IL-33 is liberated during cellular necrosis to effect paracrine signaling. We determined the subcellular localization of IL-33 and tracked its intracellular mobility and extracellular release. In contrast to published data, IL-33 localized simultaneously to nuclear euchromatin and membrane-bound cytoplasmic vesicles. Fluorescent pulse-chase fate-tracking documented dynamic nucleo-cytoplasmic flux, which was dependent on nuclear pore complex function. In murine fibroblasts in vitro and in vivo, mechanical strain induced IL-33 secretion in the absence of cellular necrosis. These data document IL-33 dynamic inter-organelle trafficking and release during biomechanical overload. As such we recharacterize IL-33 as both an inflammatory as well as mechanically responsive cytokine secreted by living cells."xsd:string |
| http://purl.uniprot.org/citations/22215666 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m111.298703"xsd:string |
| http://purl.uniprot.org/citations/22215666 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m111.298703"xsd:string |
| http://purl.uniprot.org/citations/22215666 | http://purl.uniprot.org/core/author | "Lee R.T."xsd:string |
| http://purl.uniprot.org/citations/22215666 | http://purl.uniprot.org/core/author | "Lee R.T."xsd:string |
| http://purl.uniprot.org/citations/22215666 | http://purl.uniprot.org/core/author | "Dobner S."xsd:string |
| http://purl.uniprot.org/citations/22215666 | http://purl.uniprot.org/core/author | "Dobner S."xsd:string |
| http://purl.uniprot.org/citations/22215666 | http://purl.uniprot.org/core/author | "Hei H."xsd:string |
| http://purl.uniprot.org/citations/22215666 | http://purl.uniprot.org/core/author | "Hei H."xsd:string |
| http://purl.uniprot.org/citations/22215666 | http://purl.uniprot.org/core/author | "Kakkar R."xsd:string |
| http://purl.uniprot.org/citations/22215666 | http://purl.uniprot.org/core/author | "Kakkar R."xsd:string |
| http://purl.uniprot.org/citations/22215666 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22215666 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22215666 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/22215666 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/22215666 | http://purl.uniprot.org/core/pages | "6941-6948"xsd:string |
| http://purl.uniprot.org/citations/22215666 | http://purl.uniprot.org/core/pages | "6941-6948"xsd:string |
| http://purl.uniprot.org/citations/22215666 | http://purl.uniprot.org/core/title | "Interleukin 33 as a mechanically responsive cytokine secreted by living cells."xsd:string |
| http://purl.uniprot.org/citations/22215666 | http://purl.uniprot.org/core/title | "Interleukin 33 as a mechanically responsive cytokine secreted by living cells."xsd:string |
| http://purl.uniprot.org/citations/22215666 | http://purl.uniprot.org/core/volume | "287"xsd:string |
| http://purl.uniprot.org/citations/22215666 | http://purl.uniprot.org/core/volume | "287"xsd:string |
| http://purl.uniprot.org/citations/22215666 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22215666 |
| http://purl.uniprot.org/citations/22215666 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22215666 |