| http://purl.uniprot.org/citations/22245737 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22245737 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22245737 | http://www.w3.org/2000/01/rdf-schema#comment | "The structural characteristics of the engagement of major histocompatibility complex (MHC) class II-restricted self antigens by autoreactive T cell antigen receptors (TCRs) is established, but how autoimmune TCRs interact with complexes of self peptide and MHC class I has been unclear. Here we examined how CD8(+) T cells kill human islet beta cells in type 1 diabetes via recognition of a human leukocyte antigen HLA-A*0201-restricted glucose-sensitive preproinsulin peptide by the autoreactive TCR 1E6. Rigid 'lock-and-key' binding underpinned the 1E6-HLA-A*0201-peptide interaction, whereby 1E6 docked similarly to most MHC class I-restricted TCRs. However, this interaction was extraordinarily weak because of limited contacts with MHC class I. TCR binding was highly peptide centric, dominated by two residues of the complementarity-determining region 3 (CDR3) loops that acted as an 'aromatic-cap' over the complex of peptide and MHC class I (pMHCI). Thus, highly focused peptide-centric interactions associated with suboptimal TCR-pMHCI binding affinities might lead to thymic escape and potential CD8(+) T cell-mediated autoreactivity."xsd:string |
| http://purl.uniprot.org/citations/22245737 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.2206"xsd:string |
| http://purl.uniprot.org/citations/22245737 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.2206"xsd:string |
| http://purl.uniprot.org/citations/22245737 | http://purl.uniprot.org/core/author | "Rizkallah P.J."xsd:string |
| http://purl.uniprot.org/citations/22245737 | http://purl.uniprot.org/core/author | "Rizkallah P.J."xsd:string |
| http://purl.uniprot.org/citations/22245737 | http://purl.uniprot.org/core/author | "Rossjohn J."xsd:string |
| http://purl.uniprot.org/citations/22245737 | http://purl.uniprot.org/core/author | "Rossjohn J."xsd:string |
| http://purl.uniprot.org/citations/22245737 | http://purl.uniprot.org/core/author | "Gras S."xsd:string |
| http://purl.uniprot.org/citations/22245737 | http://purl.uniprot.org/core/author | "Gras S."xsd:string |
| http://purl.uniprot.org/citations/22245737 | http://purl.uniprot.org/core/author | "Miles J.J."xsd:string |
| http://purl.uniprot.org/citations/22245737 | http://purl.uniprot.org/core/author | "Miles J.J."xsd:string |
| http://purl.uniprot.org/citations/22245737 | http://purl.uniprot.org/core/author | "Sewell A.K."xsd:string |
| http://purl.uniprot.org/citations/22245737 | http://purl.uniprot.org/core/author | "Sewell A.K."xsd:string |
| http://purl.uniprot.org/citations/22245737 | http://purl.uniprot.org/core/author | "Price D.A."xsd:string |
| http://purl.uniprot.org/citations/22245737 | http://purl.uniprot.org/core/author | "Price D.A."xsd:string |
| http://purl.uniprot.org/citations/22245737 | http://purl.uniprot.org/core/author | "Cole D.K."xsd:string |
| http://purl.uniprot.org/citations/22245737 | http://purl.uniprot.org/core/author | "Cole D.K."xsd:string |
| http://purl.uniprot.org/citations/22245737 | http://purl.uniprot.org/core/author | "Jakobsen B.K."xsd:string |
| http://purl.uniprot.org/citations/22245737 | http://purl.uniprot.org/core/author | "Jakobsen B.K."xsd:string |
| http://purl.uniprot.org/citations/22245737 | http://purl.uniprot.org/core/author | "Huang G.C."xsd:string |
| http://purl.uniprot.org/citations/22245737 | http://purl.uniprot.org/core/author | "Huang G.C."xsd:string |
| http://purl.uniprot.org/citations/22245737 | http://purl.uniprot.org/core/author | "Gostick E."xsd:string |
| http://purl.uniprot.org/citations/22245737 | http://purl.uniprot.org/core/author | "Gostick E."xsd:string |