| http://purl.uniprot.org/citations/22284419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22284419 | http://www.w3.org/2000/01/rdf-schema#comment | "The type I interferon (IFN) response initiated by detection of nucleic acids is important for antiviral defense but is also associated with specific autoimmune diseases. Mutations in the human 3' repair exonuclease 1 (Trex1) gene cause Aicardi-Goutières syndrome (AGS), an IFN-associated autoimmune disease. However, the source of the type I IFN response and the precise mechanisms of disease in AGS remain unknown. Here, we demonstrate that Trex1 is an essential negative regulator of the STING-dependent antiviral response. We used an in vivo reporter of IFN activity in Trex1-deficient mice to localize the initiation of disease to nonhematopoietic cells. These IFNs drove T cell-mediated inflammation and an autoantibody response that targeted abundant, tissue-restricted autoantigens. However, B cells contributed to mortality independently of T cell-mediated tissue damage. These findings reveal a stepwise progression of autoimmune disease in Trex1-deficient mice, with implications for the treatment of AGS and related disorders."xsd:string |
| http://purl.uniprot.org/citations/22284419 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2011.11.018"xsd:string |
| http://purl.uniprot.org/citations/22284419 | http://purl.uniprot.org/core/author | "Gale M. Jr."xsd:string |
| http://purl.uniprot.org/citations/22284419 | http://purl.uniprot.org/core/author | "Loo Y.M."xsd:string |
| http://purl.uniprot.org/citations/22284419 | http://purl.uniprot.org/core/author | "Elkon K.B."xsd:string |
| http://purl.uniprot.org/citations/22284419 | http://purl.uniprot.org/core/author | "Stetson D.B."xsd:string |
| http://purl.uniprot.org/citations/22284419 | http://purl.uniprot.org/core/author | "Barber G.N."xsd:string |
| http://purl.uniprot.org/citations/22284419 | http://purl.uniprot.org/core/author | "Gall A."xsd:string |
| http://purl.uniprot.org/citations/22284419 | http://purl.uniprot.org/core/author | "Treuting P."xsd:string |
| http://purl.uniprot.org/citations/22284419 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22284419 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/22284419 | http://purl.uniprot.org/core/pages | "120-131"xsd:string |
| http://purl.uniprot.org/citations/22284419 | http://purl.uniprot.org/core/title | "Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease."xsd:string |
| http://purl.uniprot.org/citations/22284419 | http://purl.uniprot.org/core/volume | "36"xsd:string |
| http://purl.uniprot.org/citations/22284419 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22284419 |
| http://purl.uniprot.org/citations/22284419 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22284419 |
| http://purl.uniprot.org/uniprot/P01101#attribution-AE0780F243B413D787140683F2608BEF | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22284419 |
| http://purl.uniprot.org/uniprot/#_A0A125R9I3-mappedCitation-22284419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22284419 |
| http://purl.uniprot.org/uniprot/#_A0A075B5P6-mappedCitation-22284419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22284419 |
| http://purl.uniprot.org/uniprot/#_A0A075B6A0-mappedCitation-22284419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22284419 |
| http://purl.uniprot.org/uniprot/#_A0A2R3XZC4-mappedCitation-22284419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22284419 |
| http://purl.uniprot.org/uniprot/#_A0A494B980-mappedCitation-22284419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22284419 |
| http://purl.uniprot.org/uniprot/#_A0A494B9A3-mappedCitation-22284419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22284419 |
| http://purl.uniprot.org/uniprot/#_A0A2U8RP79-mappedCitation-22284419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22284419 |