| http://purl.uniprot.org/citations/22301138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22301138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22301138 | http://www.w3.org/2000/01/rdf-schema#comment | "The interferon (IFN)-mediated antiviral response is a major defense of the host immune system. In order to complete their life cycle, viruses must modulate host IFN-mediated immune responses. Herpes simplex virus 1 (HSV-1) is a large DNA virus containing more than 80 genes, many of which encode proteins that are involved in virus-host interactions and show immune modulatory capabilities. In this study, we demonstrate that the US11 protein, an RNA binding tegument protein of HSV-1, is a novel antagonist of the beta IFN (IFN-β) pathway. US11 significantly inhibited Sendai virus (SeV)-induced IFN-β production, and its double-stranded RNA (dsRNA) binding domain was indispensable for this inhibition activity. Additionally, wild-type HSV-1 coinfection showed stronger inhibition than US11 mutant HSV-1 in SeV-induced IFN-β production. Coimmunoprecipitation analysis demonstrated that the US11 protein in HSV-1-infected cells interacts with endogenous RIG-I and MDA-5 through its C-terminal RNA-binding domain, which was RNA independent. Expression of US11 in both transfected and HSV-1-infected cells interferes with the interaction between MAVS and RIG-I or MDA-5. Finally, US11 dampens SeV-mediated IRF3 activation. Taken together, the combined data indicate that HSV-1 US11 binds to RIG-I and MDA-5 and inhibits their downstream signaling pathway, preventing the production of IFN-β, which may contribute to the pathogenesis of HSV-1 infection."xsd:string |
| http://purl.uniprot.org/citations/22301138 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.06713-11"xsd:string |
| http://purl.uniprot.org/citations/22301138 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.06713-11"xsd:string |
| http://purl.uniprot.org/citations/22301138 | http://purl.uniprot.org/core/author | "Lin R."xsd:string |
| http://purl.uniprot.org/citations/22301138 | http://purl.uniprot.org/core/author | "Lin R."xsd:string |
| http://purl.uniprot.org/citations/22301138 | http://purl.uniprot.org/core/author | "Wang S."xsd:string |
| http://purl.uniprot.org/citations/22301138 | http://purl.uniprot.org/core/author | "Wang S."xsd:string |
| http://purl.uniprot.org/citations/22301138 | http://purl.uniprot.org/core/author | "Zheng C."xsd:string |
| http://purl.uniprot.org/citations/22301138 | http://purl.uniprot.org/core/author | "Zheng C."xsd:string |
| http://purl.uniprot.org/citations/22301138 | http://purl.uniprot.org/core/author | "Xing J."xsd:string |
| http://purl.uniprot.org/citations/22301138 | http://purl.uniprot.org/core/author | "Xing J."xsd:string |
| http://purl.uniprot.org/citations/22301138 | http://purl.uniprot.org/core/author | "Mossman K.L."xsd:string |
| http://purl.uniprot.org/citations/22301138 | http://purl.uniprot.org/core/author | "Mossman K.L."xsd:string |
| http://purl.uniprot.org/citations/22301138 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22301138 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22301138 | http://purl.uniprot.org/core/name | "J. Virol."xsd:string |
| http://purl.uniprot.org/citations/22301138 | http://purl.uniprot.org/core/name | "J. Virol."xsd:string |
| http://purl.uniprot.org/citations/22301138 | http://purl.uniprot.org/core/pages | "3528-3540"xsd:string |
| http://purl.uniprot.org/citations/22301138 | http://purl.uniprot.org/core/pages | "3528-3540"xsd:string |
| http://purl.uniprot.org/citations/22301138 | http://purl.uniprot.org/core/title | "Herpes simplex virus 1 tegument protein US11 downmodulates the RLR signaling pathway via direct interaction with RIG-I and MDA-5."xsd:string |
| http://purl.uniprot.org/citations/22301138 | http://purl.uniprot.org/core/title | "Herpes simplex virus 1 tegument protein US11 downmodulates the RLR signaling pathway via direct interaction with RIG-I and MDA-5."xsd:string |
| http://purl.uniprot.org/citations/22301138 | http://purl.uniprot.org/core/volume | "86"xsd:string |
| http://purl.uniprot.org/citations/22301138 | http://purl.uniprot.org/core/volume | "86"xsd:string |