| http://purl.uniprot.org/citations/22307087 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22307087 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22307087 | http://www.w3.org/2000/01/rdf-schema#comment | "The Legionella pneumophila protein AnkX that is injected into infected cells by a Type IV secretion system transfers a phosphocholine group from CDP-choline to a serine in the Rab1 and Rab35 GTPase Switch II regions. We show here that the consequences of phosphocholination on the interaction of Rab1/Rab35 with various partner proteins are quite distinct. Activation of phosphocholinated Rabs by GTP/GDP exchange factors (GEFs) and binding to the GDP dissociation inhibitor (GDI) are strongly inhibited, whereas deactivation by GTPase activating proteins (GAPs) and interactions with Rab-effector proteins (such as LidA and MICAL-3) are only slightly inhibited. We show that the Legionella protein lpg0696 has the ability to remove the phosphocholine group from Rab1. We present a model in which the action of AnkX occurs as an alternative to GTP/GDP exchange, stabilizing phosphocholinated Rabs in membranes in the GDP form because of loss of GDI binding ability, preventing interactions with cellular GTPase effectors, which require the GTP-bound form. Generation of the GTP form of phosphocholinated Rab proteins cannot occur due to loss of interaction with cellular GEFs."xsd:string |
| http://purl.uniprot.org/citations/22307087 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2012.16"xsd:string |
| http://purl.uniprot.org/citations/22307087 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2012.16"xsd:string |
| http://purl.uniprot.org/citations/22307087 | http://purl.uniprot.org/core/author | "Goody P.R."xsd:string |
| http://purl.uniprot.org/citations/22307087 | http://purl.uniprot.org/core/author | "Goody P.R."xsd:string |
| http://purl.uniprot.org/citations/22307087 | http://purl.uniprot.org/core/author | "Goody R.S."xsd:string |
| http://purl.uniprot.org/citations/22307087 | http://purl.uniprot.org/core/author | "Goody R.S."xsd:string |
| http://purl.uniprot.org/citations/22307087 | http://purl.uniprot.org/core/author | "Heller K."xsd:string |
| http://purl.uniprot.org/citations/22307087 | http://purl.uniprot.org/core/author | "Heller K."xsd:string |
| http://purl.uniprot.org/citations/22307087 | http://purl.uniprot.org/core/author | "Itzen A."xsd:string |
| http://purl.uniprot.org/citations/22307087 | http://purl.uniprot.org/core/author | "Itzen A."xsd:string |
| http://purl.uniprot.org/citations/22307087 | http://purl.uniprot.org/core/author | "Muller M.P."xsd:string |
| http://purl.uniprot.org/citations/22307087 | http://purl.uniprot.org/core/author | "Muller M.P."xsd:string |
| http://purl.uniprot.org/citations/22307087 | http://purl.uniprot.org/core/author | "Oesterlin L.K."xsd:string |
| http://purl.uniprot.org/citations/22307087 | http://purl.uniprot.org/core/author | "Oesterlin L.K."xsd:string |
| http://purl.uniprot.org/citations/22307087 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22307087 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22307087 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/22307087 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/22307087 | http://purl.uniprot.org/core/pages | "1774-1784"xsd:string |
| http://purl.uniprot.org/citations/22307087 | http://purl.uniprot.org/core/pages | "1774-1784"xsd:string |
| http://purl.uniprot.org/citations/22307087 | http://purl.uniprot.org/core/title | "Reversible phosphocholination of Rab proteins by Legionella pneumophila effector proteins."xsd:string |
| http://purl.uniprot.org/citations/22307087 | http://purl.uniprot.org/core/title | "Reversible phosphocholination of Rab proteins by Legionella pneumophila effector proteins."xsd:string |