| http://purl.uniprot.org/citations/22365146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22365146 | http://www.w3.org/2000/01/rdf-schema#comment | "In dendritic cells (DCs) cysteine cathepsins play a key role in antigen processing, invariant chain (Ii) cleavage and regulation of cell adhesion after maturation stimuli. Cystatin F, a cysteine protease inhibitor, is present in DCs in endosomal/lysosomal vesicles and thus has a potential to modulate cathepsin activity. In immature DCs cystatin F colocalizes with cathepsin S. After induction of DC maturation however, it is translocated into lysosomes and colocalizes with cathepsin L. The inhibitory potential of cystatin F depends on the properties of the monomer. We showed that the full-length monomeric cystatin F was a 12-fold stronger inhibitor of cathepsin S than the N-terminally processed cystatin F, whereas no significant difference in inhibition was observed for cathepsins L, H and X. Therefore, the role of cystatin F in regulating the main cathepsin S function in DCs, i.e. the processing of Ii, may depend on the form of the monomer present in endosomal/lysosomal vesicles. On the other hand, intact and truncated monomeric cystatin F are both potent inhibitors of cathepsin L and it is likely that cystatin F could regulate its activity in maturing, adherent DCs, controlling the processing of procathepsin X, which promotes cell adhesion via activation of Mac-1 (CD11b/CD18) integrin receptor."xsd:string |
| http://purl.uniprot.org/citations/22365146 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ejcb.2012.01.001"xsd:string |
| http://purl.uniprot.org/citations/22365146 | http://purl.uniprot.org/core/author | "Kos J."xsd:string |
| http://purl.uniprot.org/citations/22365146 | http://purl.uniprot.org/core/author | "Renko M."xsd:string |
| http://purl.uniprot.org/citations/22365146 | http://purl.uniprot.org/core/author | "Magister S."xsd:string |
| http://purl.uniprot.org/citations/22365146 | http://purl.uniprot.org/core/author | "Obermajer N."xsd:string |
| http://purl.uniprot.org/citations/22365146 | http://purl.uniprot.org/core/author | "Svajger U."xsd:string |
| http://purl.uniprot.org/citations/22365146 | http://purl.uniprot.org/core/author | "Watts C."xsd:string |
| http://purl.uniprot.org/citations/22365146 | http://purl.uniprot.org/core/author | "Romih R."xsd:string |
| http://purl.uniprot.org/citations/22365146 | http://purl.uniprot.org/core/author | "Colbert J.D."xsd:string |
| http://purl.uniprot.org/citations/22365146 | http://purl.uniprot.org/core/author | "Mirkovic B."xsd:string |
| http://purl.uniprot.org/citations/22365146 | http://purl.uniprot.org/core/author | "Softic A."xsd:string |
| http://purl.uniprot.org/citations/22365146 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22365146 | http://purl.uniprot.org/core/name | "Eur J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/22365146 | http://purl.uniprot.org/core/pages | "391-401"xsd:string |
| http://purl.uniprot.org/citations/22365146 | http://purl.uniprot.org/core/title | "Regulation of cathepsins S and L by cystatin F during maturation of dendritic cells."xsd:string |
| http://purl.uniprot.org/citations/22365146 | http://purl.uniprot.org/core/volume | "91"xsd:string |
| http://purl.uniprot.org/citations/22365146 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22365146 |
| http://purl.uniprot.org/citations/22365146 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22365146 |
| http://purl.uniprot.org/uniprot/P25774#attribution-A2033E7BA2AB1D1F176BA3E5BF4BBEB2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22365146 |
| http://purl.uniprot.org/uniprot/P07711#attribution-A2033E7BA2AB1D1F176BA3E5BF4BBEB2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22365146 |
| http://purl.uniprot.org/uniprot/O76096#attribution-A2033E7BA2AB1D1F176BA3E5BF4BBEB2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22365146 |
| http://purl.uniprot.org/uniprot/P01034#attribution-A2033E7BA2AB1D1F176BA3E5BF4BBEB2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22365146 |
| http://purl.uniprot.org/uniprot/#_A0A7P0TB77-mappedCitation-22365146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22365146 |