| http://purl.uniprot.org/citations/22466611 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22466611 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22466611 | http://www.w3.org/2000/01/rdf-schema#comment | "Transcription-coupled nucleotide-excision repair (TC-NER) is a subpathway of NER that efficiently removes the highly toxic RNA polymerase II blocking lesions in DNA. Defective TC-NER gives rise to the human disorders Cockayne syndrome and UV-sensitive syndrome (UV(S)S). NER initiating factors are known to be regulated by ubiquitination. Using a SILAC-based proteomic approach, we identified UVSSA (formerly known as KIAA1530) as part of a UV-induced ubiquitinated protein complex. Knockdown of UVSSA resulted in TC-NER deficiency. UVSSA was found to be the causative gene for UV(S)S, an unresolved NER deficiency disorder. The UVSSA protein interacts with elongating RNA polymerase II, localizes specifically to UV-induced lesions, resides in chromatin-associated TC-NER complexes and is implicated in stabilizing the TC-NER master organizing protein ERCC6 (also known as CSB) by delivering the deubiquitinating enzyme USP7 to TC-NER complexes. Together, these findings indicate that UVSSA-USP7–mediated stabilization of ERCC6 represents a critical regulatory mechanism of TC-NER in restoring gene expression."xsd:string |
| http://purl.uniprot.org/citations/22466611 | http://purl.org/dc/terms/identifier | "doi:10.1038/ng.2230"xsd:string |
| http://purl.uniprot.org/citations/22466611 | http://purl.org/dc/terms/identifier | "doi:10.1038/ng.2230"xsd:string |
| http://purl.uniprot.org/citations/22466611 | http://purl.uniprot.org/core/author | "Vermeulen W."xsd:string |
| http://purl.uniprot.org/citations/22466611 | http://purl.uniprot.org/core/author | "Vermeulen W."xsd:string |
| http://purl.uniprot.org/citations/22466611 | http://purl.uniprot.org/core/author | "Marteijn J.A."xsd:string |
| http://purl.uniprot.org/citations/22466611 | http://purl.uniprot.org/core/author | "Marteijn J.A."xsd:string |
| http://purl.uniprot.org/citations/22466611 | http://purl.uniprot.org/core/author | "Dekkers D.H."xsd:string |
| http://purl.uniprot.org/citations/22466611 | http://purl.uniprot.org/core/author | "Dekkers D.H."xsd:string |
| http://purl.uniprot.org/citations/22466611 | http://purl.uniprot.org/core/author | "Demmers J.A."xsd:string |
| http://purl.uniprot.org/citations/22466611 | http://purl.uniprot.org/core/author | "Demmers J.A."xsd:string |
| http://purl.uniprot.org/citations/22466611 | http://purl.uniprot.org/core/author | "Fousteri M."xsd:string |
| http://purl.uniprot.org/citations/22466611 | http://purl.uniprot.org/core/author | "Fousteri M."xsd:string |
| http://purl.uniprot.org/citations/22466611 | http://purl.uniprot.org/core/author | "Hoeijmakers J.H."xsd:string |
| http://purl.uniprot.org/citations/22466611 | http://purl.uniprot.org/core/author | "Hoeijmakers J.H."xsd:string |
| http://purl.uniprot.org/citations/22466611 | http://purl.uniprot.org/core/author | "Raams A."xsd:string |
| http://purl.uniprot.org/citations/22466611 | http://purl.uniprot.org/core/author | "Raams A."xsd:string |
| http://purl.uniprot.org/citations/22466611 | http://purl.uniprot.org/core/author | "Laffeber C."xsd:string |
| http://purl.uniprot.org/citations/22466611 | http://purl.uniprot.org/core/author | "Laffeber C."xsd:string |
| http://purl.uniprot.org/citations/22466611 | http://purl.uniprot.org/core/author | "Lagarou A."xsd:string |
| http://purl.uniprot.org/citations/22466611 | http://purl.uniprot.org/core/author | "Lagarou A."xsd:string |
| http://purl.uniprot.org/citations/22466611 | http://purl.uniprot.org/core/author | "Schwertman P."xsd:string |
| http://purl.uniprot.org/citations/22466611 | http://purl.uniprot.org/core/author | "Schwertman P."xsd:string |