| http://purl.uniprot.org/citations/2250705 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2250705 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2250705 | http://www.w3.org/2000/01/rdf-schema#comment | "The t(14; 18) chromosomal translocation of human follicular B-cell lymphoma juxtaposes the bcl-2 gene with the immunoglobulin heavy chain locus. The bcl-2 immunoglobulin fusion gene is markedly deregulated resulting in inappropriately elevated levels of bcl-2 RNA and protein. Transgenic mice bearing a bcl-2 immunoglobulin minigene demonstrate a polyclonal expansion of resting yet responsive IgM-IgD B cells which display prolonged cell survival but no increase in cell cycling. Moreover, deregulated bcl-2 extends the survival of certain haematopoietic cell lines following growth-factor deprivation. By using immunolocalization studies we now demonstrate that Bcl-2 is an integral inner mitochondrial membrane protein of relative molecular mass 25,000 (25k). Overexpression of Bcl-2 blocks the apoptotic death of a pro-B-lymphocyte cell line. Thus, Bcl-2 is unique among proto-oncogenes, being localized to mitochondria and interfering with programmed cell death independent of promoting cell division."xsd:string |
| http://purl.uniprot.org/citations/2250705 | http://purl.org/dc/terms/identifier | "doi:10.1038/348334a0"xsd:string |
| http://purl.uniprot.org/citations/2250705 | http://purl.org/dc/terms/identifier | "doi:10.1038/348334a0"xsd:string |
| http://purl.uniprot.org/citations/2250705 | http://purl.uniprot.org/core/author | "Nunez G."xsd:string |
| http://purl.uniprot.org/citations/2250705 | http://purl.uniprot.org/core/author | "Nunez G."xsd:string |
| http://purl.uniprot.org/citations/2250705 | http://purl.uniprot.org/core/author | "Milliman C."xsd:string |
| http://purl.uniprot.org/citations/2250705 | http://purl.uniprot.org/core/author | "Milliman C."xsd:string |
| http://purl.uniprot.org/citations/2250705 | http://purl.uniprot.org/core/author | "Korsmeyer S.J."xsd:string |
| http://purl.uniprot.org/citations/2250705 | http://purl.uniprot.org/core/author | "Korsmeyer S.J."xsd:string |
| http://purl.uniprot.org/citations/2250705 | http://purl.uniprot.org/core/author | "Schreiber R.D."xsd:string |
| http://purl.uniprot.org/citations/2250705 | http://purl.uniprot.org/core/author | "Schreiber R.D."xsd:string |
| http://purl.uniprot.org/citations/2250705 | http://purl.uniprot.org/core/author | "Hockenbery D."xsd:string |
| http://purl.uniprot.org/citations/2250705 | http://purl.uniprot.org/core/author | "Hockenbery D."xsd:string |
| http://purl.uniprot.org/citations/2250705 | http://purl.uniprot.org/core/date | "1990"xsd:gYear |
| http://purl.uniprot.org/citations/2250705 | http://purl.uniprot.org/core/date | "1990"xsd:gYear |
| http://purl.uniprot.org/citations/2250705 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/2250705 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/2250705 | http://purl.uniprot.org/core/pages | "334-336"xsd:string |
| http://purl.uniprot.org/citations/2250705 | http://purl.uniprot.org/core/pages | "334-336"xsd:string |
| http://purl.uniprot.org/citations/2250705 | http://purl.uniprot.org/core/title | "Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death."xsd:string |
| http://purl.uniprot.org/citations/2250705 | http://purl.uniprot.org/core/title | "Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death."xsd:string |
| http://purl.uniprot.org/citations/2250705 | http://purl.uniprot.org/core/volume | "348"xsd:string |
| http://purl.uniprot.org/citations/2250705 | http://purl.uniprot.org/core/volume | "348"xsd:string |