| http://purl.uniprot.org/citations/22595380 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22595380 | http://www.w3.org/2000/01/rdf-schema#comment | "Abdominal aortic aneurysm (AAA) pathogenesis is distinguished by vessel wall inflammation. Cyclooxygenase (COX)-2 and microsomal prostaglandin E synthase-1, key components of the most well-characterized inflammatory prostaglandin pathway, contribute to AAA development in the 28-day angiotensin II infusion model in mice. In this study, we used this model to examine the role of the prostaglandin E receptor subtype 4 (EP4) and genetic knockdown of COX-2 expression (70% to 90%) in AAA pathogenesis. The administration of the prostaglandin receptor EP4 antagonist AE3-208 (10 mg/kg per day) to apolipoprotein E (apoE)-deficient mice led to active drug plasma concentrations and reduced AAA incidence and severity compared with control apoE-deficient mice (P < 0.01), whereas COX-2 genetic knockdown/apoE-deficient mice displayed only a minor, nonsignificant decrease in incidence of AAA. EP4 receptor protein was present in human and mouse AAA, as observed by using Western blot analysis. Aortas from AE3-208-treated mice displayed evidence of a reduced inflammatory phenotype compared with controls. Atherosclerotic lesion size at the aortic root was similar between all groups. In conclusion, the prostaglandin E(2)-EP4 signaling pathway plays a role in the AAA inflammatory process. Blocking the EP4 receptor pharmacologically reduces both the incidence and severity of AAA in the angiotensin II mouse model, potentially via attenuation of cytokine/chemokine synthesis and the reduction of matrix metalloproteinase activities."xsd:string |
| http://purl.uniprot.org/citations/22595380 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ajpath.2012.03.016"xsd:string |
| http://purl.uniprot.org/citations/22595380 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/22595380 | http://purl.uniprot.org/core/author | "Maruyama T."xsd:string |
| http://purl.uniprot.org/citations/22595380 | http://purl.uniprot.org/core/author | "Song H."xsd:string |
| http://purl.uniprot.org/citations/22595380 | http://purl.uniprot.org/core/author | "Yoon S.H."xsd:string |
| http://purl.uniprot.org/citations/22595380 | http://purl.uniprot.org/core/author | "Funk C.D."xsd:string |
| http://purl.uniprot.org/citations/22595380 | http://purl.uniprot.org/core/author | "Brown P.M."xsd:string |
| http://purl.uniprot.org/citations/22595380 | http://purl.uniprot.org/core/author | "Wang C.P."xsd:string |
| http://purl.uniprot.org/citations/22595380 | http://purl.uniprot.org/core/author | "Cao R.Y."xsd:string |
| http://purl.uniprot.org/citations/22595380 | http://purl.uniprot.org/core/author | "St Amand T."xsd:string |
| http://purl.uniprot.org/citations/22595380 | http://purl.uniprot.org/core/author | "Zelt D.T."xsd:string |
| http://purl.uniprot.org/citations/22595380 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22595380 | http://purl.uniprot.org/core/name | "Am J Pathol"xsd:string |
| http://purl.uniprot.org/citations/22595380 | http://purl.uniprot.org/core/pages | "313-321"xsd:string |
| http://purl.uniprot.org/citations/22595380 | http://purl.uniprot.org/core/title | "Prostaglandin receptor EP4 in abdominal aortic aneurysms."xsd:string |
| http://purl.uniprot.org/citations/22595380 | http://purl.uniprot.org/core/volume | "181"xsd:string |
| http://purl.uniprot.org/citations/22595380 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22595380 |
| http://purl.uniprot.org/citations/22595380 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22595380 |
| http://purl.uniprot.org/uniprot/#_A0A087WPT2-mappedCitation-22595380 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22595380 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GX15-mappedCitation-22595380 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22595380 |
| http://purl.uniprot.org/uniprot/#_G3UWN5-mappedCitation-22595380 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22595380 |
| http://purl.uniprot.org/uniprot/#_G3UWW2-mappedCitation-22595380 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22595380 |
| http://purl.uniprot.org/uniprot/#_G3UZM8-mappedCitation-22595380 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22595380 |