| http://purl.uniprot.org/citations/2261637 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2261637 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2261637 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-6 (IL-6) signal is transduced through a membrane glycoprotein, gp130, which associates with IL-6 receptor (IL-6-R). A cDNA encoding human gp130 has been cloned, revealing that it consists of 918 amino acids with a single transmembrane domain. The extracellular region comprises six units of a fibronectin type III module, and part of this region of approximately 200 amino acids has features typical of a cytokine receptor family. A cDNA-expressed gp130 showed no binding property to IL-6 or several other cytokines. Although a transfectant with an IL-6-R cDNA expressed mainly low affinity IL-6 binding sites, an increase in high affinity binding sites was observed after cotransfection with a gp130 cDNA. This confirmed that a gp130 is involved in the formation of high affinity IL-6 binding sites. A cloned gp130 could associate with a complex of IL-6 and soluble IL-6-R and transduce the growth signal when expressed in a murine IL-3-dependent cell line."xsd:string |
| http://purl.uniprot.org/citations/2261637 | http://purl.org/dc/terms/identifier | "doi:10.1016/0092-8674(90)90411-7"xsd:string |
| http://purl.uniprot.org/citations/2261637 | http://purl.org/dc/terms/identifier | "doi:10.1016/0092-8674(90)90411-7"xsd:string |
| http://purl.uniprot.org/citations/2261637 | http://purl.uniprot.org/core/author | "Kishimoto T."xsd:string |
| http://purl.uniprot.org/citations/2261637 | http://purl.uniprot.org/core/author | "Kishimoto T."xsd:string |
| http://purl.uniprot.org/citations/2261637 | http://purl.uniprot.org/core/author | "Murakami M."xsd:string |
| http://purl.uniprot.org/citations/2261637 | http://purl.uniprot.org/core/author | "Murakami M."xsd:string |
| http://purl.uniprot.org/citations/2261637 | http://purl.uniprot.org/core/author | "Saito M."xsd:string |
| http://purl.uniprot.org/citations/2261637 | http://purl.uniprot.org/core/author | "Saito M."xsd:string |
| http://purl.uniprot.org/citations/2261637 | http://purl.uniprot.org/core/author | "Hirano T."xsd:string |
| http://purl.uniprot.org/citations/2261637 | http://purl.uniprot.org/core/author | "Hirano T."xsd:string |
| http://purl.uniprot.org/citations/2261637 | http://purl.uniprot.org/core/author | "Hibi M."xsd:string |
| http://purl.uniprot.org/citations/2261637 | http://purl.uniprot.org/core/author | "Hibi M."xsd:string |
| http://purl.uniprot.org/citations/2261637 | http://purl.uniprot.org/core/author | "Taga T."xsd:string |
| http://purl.uniprot.org/citations/2261637 | http://purl.uniprot.org/core/author | "Taga T."xsd:string |
| http://purl.uniprot.org/citations/2261637 | http://purl.uniprot.org/core/date | "1990"xsd:gYear |
| http://purl.uniprot.org/citations/2261637 | http://purl.uniprot.org/core/date | "1990"xsd:gYear |
| http://purl.uniprot.org/citations/2261637 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/2261637 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/2261637 | http://purl.uniprot.org/core/pages | "1149-1157"xsd:string |
| http://purl.uniprot.org/citations/2261637 | http://purl.uniprot.org/core/pages | "1149-1157"xsd:string |
| http://purl.uniprot.org/citations/2261637 | http://purl.uniprot.org/core/title | "Molecular cloning and expression of an IL-6 signal transducer, gp130."xsd:string |
| http://purl.uniprot.org/citations/2261637 | http://purl.uniprot.org/core/title | "Molecular cloning and expression of an IL-6 signal transducer, gp130."xsd:string |