| http://purl.uniprot.org/citations/22617848 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22617848 | http://www.w3.org/2000/01/rdf-schema#comment | "Glia-guided migration (glia-guided locomotion) during radial migration is a characteristic yet unique mode of migration. In this process, the directionality of migration is predetermined by glial processes and not by growth cones. Prior to the initiation of glia-guided migration, migrating neurons transform from multipolar to bipolar, but the molecular mechanisms underlying this multipolar-bipolar transition and the commencement of glia-guided migration are not fully understood. Here, we demonstrate that the multipolar-bipolar transition is not solely a cell autonomous event; instead, the interaction of growth cones with glial processes plays an essential role. Time-lapse imaging with lattice assays reveals the importance of vigorously active growth cones in searching for appropriate glial scaffolds, completing the transition, and initiating glia-guided migration. These growth cone activities are regulated by Abl kinase and Cdk5 via WAVE2-Abi2 through the phosphorylation of tyrosine 150 and serine 137 of WAVE2. Neurons that do not display such growth cone activities are mispositioned in a more superficial location in the neocortex, suggesting the significance of growth cones for the final location of the neurons. This process occurs in spite of the "inside-out" principle in which later-born neurons are situated more superficially."xsd:string |
| http://purl.uniprot.org/citations/22617848 | http://purl.org/dc/terms/identifier | "doi:10.1093/cercor/bhs123"xsd:string |
| http://purl.uniprot.org/citations/22617848 | http://purl.uniprot.org/core/author | "Kuroda K."xsd:string |
| http://purl.uniprot.org/citations/22617848 | http://purl.uniprot.org/core/author | "Miyata T."xsd:string |
| http://purl.uniprot.org/citations/22617848 | http://purl.uniprot.org/core/author | "Sato M."xsd:string |
| http://purl.uniprot.org/citations/22617848 | http://purl.uniprot.org/core/author | "Zhao H."xsd:string |
| http://purl.uniprot.org/citations/22617848 | http://purl.uniprot.org/core/author | "Wang C.C."xsd:string |
| http://purl.uniprot.org/citations/22617848 | http://purl.uniprot.org/core/author | "Nagata K."xsd:string |
| http://purl.uniprot.org/citations/22617848 | http://purl.uniprot.org/core/author | "Oka Y."xsd:string |
| http://purl.uniprot.org/citations/22617848 | http://purl.uniprot.org/core/author | "Komada M."xsd:string |
| http://purl.uniprot.org/citations/22617848 | http://purl.uniprot.org/core/author | "Yagi H."xsd:string |
| http://purl.uniprot.org/citations/22617848 | http://purl.uniprot.org/core/author | "Iguchi T."xsd:string |
| http://purl.uniprot.org/citations/22617848 | http://purl.uniprot.org/core/author | "Sakakibara A."xsd:string |
| http://purl.uniprot.org/citations/22617848 | http://purl.uniprot.org/core/author | "Xie M.J."xsd:string |
| http://purl.uniprot.org/citations/22617848 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/22617848 | http://purl.uniprot.org/core/name | "Cereb Cortex"xsd:string |
| http://purl.uniprot.org/citations/22617848 | http://purl.uniprot.org/core/pages | "1410-1423"xsd:string |
| http://purl.uniprot.org/citations/22617848 | http://purl.uniprot.org/core/title | "WAVE2-Abi2 complex controls growth cone activity and regulates the multipolar-bipolar transition as well as the initiation of glia-guided migration."xsd:string |
| http://purl.uniprot.org/citations/22617848 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/22617848 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22617848 |
| http://purl.uniprot.org/citations/22617848 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22617848 |
| http://purl.uniprot.org/uniprot/#_A0A087WPP8-mappedCitation-22617848 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22617848 |
| http://purl.uniprot.org/uniprot/#_A0A087WNT3-mappedCitation-22617848 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22617848 |
| http://purl.uniprot.org/uniprot/#_A0A087WNU9-mappedCitation-22617848 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22617848 |