| http://purl.uniprot.org/citations/22641345 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22641345 | http://www.w3.org/2000/01/rdf-schema#comment | "Continuously dividing cells must be protected from telomeric and nontelomeric DNA damage in order to maintain their proliferative potential. Here, we report a novel telomere-protecting mechanism regulated by nucleostemin (NS). NS depletion increased the number of telomere damage foci in both telomerase-active (TA(+)) and alternative lengthening of telomere (ALT) cells and decreased the percentage of damaged telomeres associated with ALT-associated PML bodies (APB) and the number of APB in ALT cells. Mechanistically, NS could promote the recruitment of PML-IV to SUMOylated TRF1 in TA(+) and ALT cells. This event was stimulated by DNA damage. Supporting the importance of NS and PML-IV in telomere protection, we demonstrate that loss of NS or PML-IV increased the frequency of telomere damage and aberration, reduced telomeric length, and perturbed the TRF2(ΔBΔM)-induced telomeric recruitment of RAD51. Conversely, overexpression of either NS or PML-IV protected ALT and TA(+) cells from telomere damage. This work reveals a novel mechanism in telomere protection."xsd:string |
| http://purl.uniprot.org/citations/22641345 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201109038"xsd:string |
| http://purl.uniprot.org/citations/22641345 | http://purl.uniprot.org/core/author | "Lin T."xsd:string |
| http://purl.uniprot.org/citations/22641345 | http://purl.uniprot.org/core/author | "Hsu J.K."xsd:string |
| http://purl.uniprot.org/citations/22641345 | http://purl.uniprot.org/core/author | "Tsai R.Y."xsd:string |
| http://purl.uniprot.org/citations/22641345 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22641345 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/22641345 | http://purl.uniprot.org/core/pages | "613-624"xsd:string |
| http://purl.uniprot.org/citations/22641345 | http://purl.uniprot.org/core/title | "Nucleostemin prevents telomere damage by promoting PML-IV recruitment to SUMOylated TRF1."xsd:string |
| http://purl.uniprot.org/citations/22641345 | http://purl.uniprot.org/core/volume | "197"xsd:string |
| http://purl.uniprot.org/citations/22641345 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22641345 |
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| http://purl.uniprot.org/uniprot/Q9BVP2#attribution-366ABC42885427A6F683F8BF849CA410 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22641345 |
| http://purl.uniprot.org/uniprot/Q9BVP2#attribution-C8CDBBE39AD62C4155C53910ACDC8DEA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22641345 |
| http://purl.uniprot.org/uniprot/P29590#attribution-366ABC42885427A6F683F8BF849CA410 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22641345 |
| http://purl.uniprot.org/uniprot/P29590#attribution-C8CDBBE39AD62C4155C53910ACDC8DEA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22641345 |
| http://purl.uniprot.org/uniprot/#_P54274-mappedCitation-22641345 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22641345 |
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| http://purl.uniprot.org/uniprot/#_Q9BVP2-mappedCitation-22641345 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22641345 |
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| http://purl.uniprot.org/uniprot/Q5QGN5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22641345 |