| http://purl.uniprot.org/citations/22681692 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22681692 | http://www.w3.org/2000/01/rdf-schema#comment | "NMDA receptor (NMDAR) channels allow Ca(2+) influx only during correlated activation of both pre- and postsynaptic cells; a Mg(2+) block mechanism suppresses NMDAR activity when the postsynaptic cell is inactive. Although the importance of NMDARs in associative learning and long-term memory (LTM) formation has been demonstrated, the role of Mg(2+) block in these processes remains unclear. Using transgenic flies expressing NMDARs defective for Mg(2+) block, we found that Mg(2+) block mutants are defective for LTM formation but not associative learning. We demonstrate that LTM-dependent increases in expression of synaptic genes, including homer, staufen, and activin, are abolished in flies expressing Mg(2+) block defective NMDARs. Furthermore, we show that genetic and pharmacological reduction of Mg(2+) block significantly increases expression of a CREB repressor isoform. Our results suggest that Mg(2+) block of NMDARs functions to suppress basal expression of a CREB repressor, thus permitting CREB-dependent gene expression upon LTM induction."xsd:string |
| http://purl.uniprot.org/citations/22681692 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2012.03.039"xsd:string |
| http://purl.uniprot.org/citations/22681692 | http://purl.uniprot.org/core/author | "Oda Y."xsd:string |
| http://purl.uniprot.org/citations/22681692 | http://purl.uniprot.org/core/author | "Morimoto T."xsd:string |
| http://purl.uniprot.org/citations/22681692 | http://purl.uniprot.org/core/author | "Horiuchi J."xsd:string |
| http://purl.uniprot.org/citations/22681692 | http://purl.uniprot.org/core/author | "Yin J.C."xsd:string |
| http://purl.uniprot.org/citations/22681692 | http://purl.uniprot.org/core/author | "Miyashita T."xsd:string |
| http://purl.uniprot.org/citations/22681692 | http://purl.uniprot.org/core/author | "Saitoe M."xsd:string |
| http://purl.uniprot.org/citations/22681692 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22681692 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/22681692 | http://purl.uniprot.org/core/pages | "887-898"xsd:string |
| http://purl.uniprot.org/citations/22681692 | http://purl.uniprot.org/core/title | "Mg(2+) block of Drosophila NMDA receptors is required for long-term memory formation and CREB-dependent gene expression."xsd:string |
| http://purl.uniprot.org/citations/22681692 | http://purl.uniprot.org/core/volume | "74"xsd:string |
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