| http://purl.uniprot.org/citations/22705373 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22705373 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22705373 | http://www.w3.org/2000/01/rdf-schema#comment | "Detection of foreign materials is the first step of successful immune responses. Stimulator of interferon genes (STING) was shown to directly bind cyclic diguanylate monophosphate (c-di-GMP), a bacterial second messenger, and to elicit strong interferon responses. Here we elucidate the structural features of the cytosolic c-di-GMP binding domain (CBD) of STING and its complex with c-di-GMP. The CBD exhibits an α + β fold and is a dimer in the crystal and in solution. Surprisingly, one c-di-GMP molecule binds to the central crevice of a STING dimer, using a series of stacking and hydrogen bonding interactions. We show that STING is autoinhibited by an intramolecular interaction between the CBD and the C-terminal tail (CTT) and that c-di-GMP releases STING from this autoinhibition by displacing the CTT. The structures provide a remarkable example of pathogen-host interactions in which a unique microbial molecule directly engages the innate immune system."xsd:string |
| http://purl.uniprot.org/citations/22705373 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2012.05.029"xsd:string |
| http://purl.uniprot.org/citations/22705373 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2012.05.029"xsd:string |
| http://purl.uniprot.org/citations/22705373 | http://purl.uniprot.org/core/author | "Eck M.J."xsd:string |
| http://purl.uniprot.org/citations/22705373 | http://purl.uniprot.org/core/author | "Eck M.J."xsd:string |
| http://purl.uniprot.org/citations/22705373 | http://purl.uniprot.org/core/author | "Jiang X."xsd:string |
| http://purl.uniprot.org/citations/22705373 | http://purl.uniprot.org/core/author | "Jiang X."xsd:string |
| http://purl.uniprot.org/citations/22705373 | http://purl.uniprot.org/core/author | "Chen Z.J."xsd:string |
| http://purl.uniprot.org/citations/22705373 | http://purl.uniprot.org/core/author | "Chen Z.J."xsd:string |
| http://purl.uniprot.org/citations/22705373 | http://purl.uniprot.org/core/author | "Tian Y."xsd:string |
| http://purl.uniprot.org/citations/22705373 | http://purl.uniprot.org/core/author | "Tian Y."xsd:string |
| http://purl.uniprot.org/citations/22705373 | http://purl.uniprot.org/core/author | "Wu H."xsd:string |
| http://purl.uniprot.org/citations/22705373 | http://purl.uniprot.org/core/author | "Wu H."xsd:string |
| http://purl.uniprot.org/citations/22705373 | http://purl.uniprot.org/core/author | "Yin Q."xsd:string |
| http://purl.uniprot.org/citations/22705373 | http://purl.uniprot.org/core/author | "Yin Q."xsd:string |
| http://purl.uniprot.org/citations/22705373 | http://purl.uniprot.org/core/author | "Kabaleeswaran V."xsd:string |
| http://purl.uniprot.org/citations/22705373 | http://purl.uniprot.org/core/author | "Kabaleeswaran V."xsd:string |
| http://purl.uniprot.org/citations/22705373 | http://purl.uniprot.org/core/author | "Tu D."xsd:string |
| http://purl.uniprot.org/citations/22705373 | http://purl.uniprot.org/core/author | "Tu D."xsd:string |
| http://purl.uniprot.org/citations/22705373 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22705373 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22705373 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/22705373 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |