| http://purl.uniprot.org/citations/22738913 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22738913 | http://www.w3.org/2000/01/rdf-schema#comment | "NFAT transcription factors control T-cell activation and function. Specifically, the transcription factor NFATc2 affects the regulation of cell differentiation and growth and plays a critical role in the development of colonic inflammation. Here, we used an experimental model of colitis-associated colorectal carcinoma to investigate the contribution of NFATc2 to the promotion of colonic tumors. Compared with wild-type animals that readily presented with multiple colon tumors, NFATc2-deficient mice were protected from tumor development. This observed decrease in colonic tumor progression was associated with reduced endoscopic inflammation, increased apoptosis of lamina propria T lymphocytes, and significantly reduced levels of the critical proinflammatory cytokines interleukin (IL)-21 and IL-6. Administration of hyper IL-6 abrogated protection from tumor progression in NFATc2-knockout mice and restored tumor incidence to control levels. Taken together, our findings highlight a pivotal role for NFATc2 in the establishment of inflammation-associated colorectal tumors mediated by control of IL-6 expression."xsd:string |
| http://purl.uniprot.org/citations/22738913 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-11-4155"xsd:string |
| http://purl.uniprot.org/citations/22738913 | http://purl.uniprot.org/core/author | "Nikolaev A."xsd:string |
| http://purl.uniprot.org/citations/22738913 | http://purl.uniprot.org/core/author | "Rose-John S."xsd:string |
| http://purl.uniprot.org/citations/22738913 | http://purl.uniprot.org/core/author | "Neurath M.F."xsd:string |
| http://purl.uniprot.org/citations/22738913 | http://purl.uniprot.org/core/author | "Weigmann B."xsd:string |
| http://purl.uniprot.org/citations/22738913 | http://purl.uniprot.org/core/author | "Atreya R."xsd:string |
| http://purl.uniprot.org/citations/22738913 | http://purl.uniprot.org/core/author | "Daniel C."xsd:string |
| http://purl.uniprot.org/citations/22738913 | http://purl.uniprot.org/core/author | "Lehr H.A."xsd:string |
| http://purl.uniprot.org/citations/22738913 | http://purl.uniprot.org/core/author | "Gerlach K."xsd:string |
| http://purl.uniprot.org/citations/22738913 | http://purl.uniprot.org/core/author | "Gerlach T."xsd:string |
| http://purl.uniprot.org/citations/22738913 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22738913 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/22738913 | http://purl.uniprot.org/core/pages | "4340-4350"xsd:string |
| http://purl.uniprot.org/citations/22738913 | http://purl.uniprot.org/core/title | "Transcription factor NFATc2 controls the emergence of colon cancer associated with IL-6-dependent colitis."xsd:string |
| http://purl.uniprot.org/citations/22738913 | http://purl.uniprot.org/core/volume | "72"xsd:string |
| http://purl.uniprot.org/citations/22738913 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22738913 |
| http://purl.uniprot.org/citations/22738913 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22738913 |
| http://purl.uniprot.org/uniprot/#_A2AQC8-mappedCitation-22738913 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22738913 |
| http://purl.uniprot.org/uniprot/#_B5B2P6-mappedCitation-22738913 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22738913 |
| http://purl.uniprot.org/uniprot/#_B5B2P7-mappedCitation-22738913 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22738913 |
| http://purl.uniprot.org/uniprot/#_B5B2P8-mappedCitation-22738913 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22738913 |
| http://purl.uniprot.org/uniprot/#_B5B2Q2-mappedCitation-22738913 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22738913 |
| http://purl.uniprot.org/uniprot/#_B5B2Q4-mappedCitation-22738913 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22738913 |