| http://purl.uniprot.org/citations/22750946 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22750946 | http://www.w3.org/2000/01/rdf-schema#comment | "Many of the more than 20 mammalian proteins with N-BAR domains control cell architecture and endocytosis by associating with curved sections of the plasma membrane. It is not well understood whether N-BAR proteins are recruited directly by processes that mechanically curve the plasma membrane or indirectly by plasma-membrane-associated adaptor proteins that recruit proteins with N-BAR domains that then induce membrane curvature. Here, we show that externally induced inward deformation of the plasma membrane by cone-shaped nanostructures (nanocones) and internally induced inward deformation by contracting actin cables both trigger recruitment of isolated N-BAR domains to the curved plasma membrane. Markedly, live-cell imaging in adherent cells showed selective recruitment of full-length N-BAR proteins and isolated N-BAR domains to plasma membrane sub-regions above nanocone stripes. Electron microscopy confirmed that N-BAR domains are recruited to local membrane sites curved by nanocones. We further showed that N-BAR domains are periodically recruited to curved plasma membrane sites during local lamellipodia retraction in the front of migrating cells. Recruitment required myosin-II-generated force applied to plasma-membrane-connected actin cables. Together, our results show that N-BAR domains can be directly recruited to the plasma membrane by external push or internal pull forces that locally curve the plasma membrane."xsd:string |
| http://purl.uniprot.org/citations/22750946 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb2533"xsd:string |
| http://purl.uniprot.org/citations/22750946 | http://purl.uniprot.org/core/author | "Meyer T."xsd:string |
| http://purl.uniprot.org/citations/22750946 | http://purl.uniprot.org/core/author | "Joubert L.M."xsd:string |
| http://purl.uniprot.org/citations/22750946 | http://purl.uniprot.org/core/author | "Cui Y."xsd:string |
| http://purl.uniprot.org/citations/22750946 | http://purl.uniprot.org/core/author | "Jeong S."xsd:string |
| http://purl.uniprot.org/citations/22750946 | http://purl.uniprot.org/core/author | "Hahn K.M."xsd:string |
| http://purl.uniprot.org/citations/22750946 | http://purl.uniprot.org/core/author | "Galic M."xsd:string |
| http://purl.uniprot.org/citations/22750946 | http://purl.uniprot.org/core/author | "Tsai F.C."xsd:string |
| http://purl.uniprot.org/citations/22750946 | http://purl.uniprot.org/core/author | "Wu Y.I."xsd:string |
| http://purl.uniprot.org/citations/22750946 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22750946 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/22750946 | http://purl.uniprot.org/core/pages | "874-881"xsd:string |
| http://purl.uniprot.org/citations/22750946 | http://purl.uniprot.org/core/title | "External push and internal pull forces recruit curvature-sensing N-BAR domain proteins to the plasma membrane."xsd:string |
| http://purl.uniprot.org/citations/22750946 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/22750946 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22750946 |
| http://purl.uniprot.org/citations/22750946 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22750946 |
| http://purl.uniprot.org/uniprot/P49418#attribution-D52CDD4CC4CF64DF483C024F246423EA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22750946 |
| http://purl.uniprot.org/uniprot/P68033#attribution-DEA2797DC7E065FBFEBEA759EC018827 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22750946 |
| http://purl.uniprot.org/uniprot/P26883#attribution-84F10D7D60D233C2D7E86D3B1BE614A3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22750946 |
| http://purl.uniprot.org/uniprot/P63001#attribution-A7B0D589F638BF5084C1ACBB3D693807 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22750946 |
| http://purl.uniprot.org/uniprot/Q3UIA2#attribution-A7B0D589F638BF5084C1ACBB3D693807 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22750946 |
| http://purl.uniprot.org/uniprot/Q17R89#attribution-D52CDD4CC4CF64DF483C024F246423EA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22750946 |
| http://purl.uniprot.org/uniprot/Q60610#attribution-A7B0D589F638BF5084C1ACBB3D693807 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22750946 |