| http://purl.uniprot.org/citations/22767602 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22767602 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22767602 | http://www.w3.org/2000/01/rdf-schema#comment | "Tau exon 10, which encodes the second microtubule-binding repeat, is regulated by alternative splicing. Its alternative splicing generates Tau isoforms with three- or four-microtubule-binding repeats, named 3R-tau and 4R-tau. Adult human brain expresses equal levels of 3R-tau and 4R-tau. Imbalance of 3R-tau and 4R-tau causes Tau aggregation and neurofibrillary degeneration. In the present study, we found that splicing factor SRp55 (serine/arginine-rich protein 55) promoted Tau exon 10 inclusion. Knockdown of SRp55 significantly promoted Tau exon 10 exclusion. The promotion of Tau exon 10 inclusion by SRp55 required the arginine/serine-rich region, which was responsible for the subnucleic speckle localization. Dyrk1A (dual specificity tyrosine-phosphorylated and regulated kinase 1A) interacted with SRp55 and mainly phosphorylated its proline-rich domain. Phosphorylation of SRp55 by Dyrk1A suppressed its ability to promote Tau exon 10 inclusion. Up-regulation of Dyrk1A as in Down syndrome could lead to neurofibrillary degeneration by shifting the alternative splicing of Tau exon 10 to an increase in the ratio of 3R-tau/4R-tau."xsd:string |
| http://purl.uniprot.org/citations/22767602 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m112.355412"xsd:string |
| http://purl.uniprot.org/citations/22767602 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m112.355412"xsd:string |
| http://purl.uniprot.org/citations/22767602 | http://purl.uniprot.org/core/author | "Gu J."xsd:string |
| http://purl.uniprot.org/citations/22767602 | http://purl.uniprot.org/core/author | "Gu J."xsd:string |
| http://purl.uniprot.org/citations/22767602 | http://purl.uniprot.org/core/author | "Liu F."xsd:string |
| http://purl.uniprot.org/citations/22767602 | http://purl.uniprot.org/core/author | "Liu F."xsd:string |
| http://purl.uniprot.org/citations/22767602 | http://purl.uniprot.org/core/author | "Shi J."xsd:string |
| http://purl.uniprot.org/citations/22767602 | http://purl.uniprot.org/core/author | "Shi J."xsd:string |
| http://purl.uniprot.org/citations/22767602 | http://purl.uniprot.org/core/author | "Zhou J."xsd:string |
| http://purl.uniprot.org/citations/22767602 | http://purl.uniprot.org/core/author | "Zhou J."xsd:string |
| http://purl.uniprot.org/citations/22767602 | http://purl.uniprot.org/core/author | "Yin X."xsd:string |
| http://purl.uniprot.org/citations/22767602 | http://purl.uniprot.org/core/author | "Yin X."xsd:string |
| http://purl.uniprot.org/citations/22767602 | http://purl.uniprot.org/core/author | "Jin N."xsd:string |
| http://purl.uniprot.org/citations/22767602 | http://purl.uniprot.org/core/author | "Jin N."xsd:string |
| http://purl.uniprot.org/citations/22767602 | http://purl.uniprot.org/core/author | "Grundke-Iqbal I."xsd:string |
| http://purl.uniprot.org/citations/22767602 | http://purl.uniprot.org/core/author | "Grundke-Iqbal I."xsd:string |
| http://purl.uniprot.org/citations/22767602 | http://purl.uniprot.org/core/author | "Iqbal K."xsd:string |
| http://purl.uniprot.org/citations/22767602 | http://purl.uniprot.org/core/author | "Iqbal K."xsd:string |
| http://purl.uniprot.org/citations/22767602 | http://purl.uniprot.org/core/author | "Gong C.X."xsd:string |
| http://purl.uniprot.org/citations/22767602 | http://purl.uniprot.org/core/author | "Gong C.X."xsd:string |
| http://purl.uniprot.org/citations/22767602 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22767602 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |