| http://purl.uniprot.org/citations/22827337 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22827337 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22827337 | http://www.w3.org/2000/01/rdf-schema#comment | "The extent and duration of MAPK (mitogen-activated protein kinase) signalling govern a diversity of normal and aberrant cellular outcomes. Genetic and pharmacological disruption of the MAPK-activated kinase RSK (ribosomal S6 kinase) leads to elevated MAPK activity indicative of a RSK-dependent negative feedback loop. Using biochemical, pharmacological and quantitative MS approaches we show that RSK phosphorylates the Ras activator SOS1 (Son of Sevenless homologue 1) in cultured cells on two C-terminal residues, Ser(1134) and Ser(1161). Furthermore, we find that RSK-dependent SOS1 phosphorylation creates 14-3-3-binding sites. We show that mutating Ser(1134) and Ser(1161) disrupts 14-3-3 binding and modestly increases and extends MAPK activation. Together these data suggest that one mechanism whereby RSK negatively regulates MAPK activation is via site-specific SOS1 phosphorylation."xsd:string |
| http://purl.uniprot.org/citations/22827337 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj20120938"xsd:string |
| http://purl.uniprot.org/citations/22827337 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj20120938"xsd:string |
| http://purl.uniprot.org/citations/22827337 | http://purl.uniprot.org/core/author | "Ballif B.A."xsd:string |
| http://purl.uniprot.org/citations/22827337 | http://purl.uniprot.org/core/author | "Ballif B.A."xsd:string |
| http://purl.uniprot.org/citations/22827337 | http://purl.uniprot.org/core/author | "Carriere A."xsd:string |
| http://purl.uniprot.org/citations/22827337 | http://purl.uniprot.org/core/author | "Carriere A."xsd:string |
| http://purl.uniprot.org/citations/22827337 | http://purl.uniprot.org/core/author | "Cheerathodi M."xsd:string |
| http://purl.uniprot.org/citations/22827337 | http://purl.uniprot.org/core/author | "Cheerathodi M."xsd:string |
| http://purl.uniprot.org/citations/22827337 | http://purl.uniprot.org/core/author | "Lavoie G."xsd:string |
| http://purl.uniprot.org/citations/22827337 | http://purl.uniprot.org/core/author | "Lavoie G."xsd:string |
| http://purl.uniprot.org/citations/22827337 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/22827337 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/22827337 | http://purl.uniprot.org/core/author | "Roux P.P."xsd:string |
| http://purl.uniprot.org/citations/22827337 | http://purl.uniprot.org/core/author | "Roux P.P."xsd:string |
| http://purl.uniprot.org/citations/22827337 | http://purl.uniprot.org/core/author | "Rush J."xsd:string |
| http://purl.uniprot.org/citations/22827337 | http://purl.uniprot.org/core/author | "Rush J."xsd:string |
| http://purl.uniprot.org/citations/22827337 | http://purl.uniprot.org/core/author | "Saha M."xsd:string |
| http://purl.uniprot.org/citations/22827337 | http://purl.uniprot.org/core/author | "Saha M."xsd:string |
| http://purl.uniprot.org/citations/22827337 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22827337 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22827337 | http://purl.uniprot.org/core/name | "Biochem. J."xsd:string |
| http://purl.uniprot.org/citations/22827337 | http://purl.uniprot.org/core/name | "Biochem. J."xsd:string |