| http://purl.uniprot.org/citations/22948820 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22948820 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22948820 | http://www.w3.org/2000/01/rdf-schema#comment | "Valosin-containing protein (VCP, also called p97) is an essential and highly conserved adenosine triphosphate-dependent chaperone implicated in a wide range of cellular processes in eukaryotes, and mild VCP mutations can cause severe neurodegenerative disease. Here we show that mammalian VCP is trimethylated on Lys315 in a variety of cell lines and tissues, and that the previously uncharacterized protein METTL21D (denoted here as VCP lysine methyltransferase, VCP-KMT) is the responsible enzyme. VCP methylation was abolished in three human VCP-KMT knockout cell lines generated with zinc-finger nucleases. Interestingly, VCP-KMT was recently reported to promote tumour metastasis, and indeed, VCP-KMT-deficient cells displayed reduced growth rate, migration and invasive potential. Finally, we present data indicating that VCP-KMT, calmodulin-lysine methyltransferase and eight uncharacterized proteins together constitute a novel human protein methyltransferase family. The present work provides new insights on protein methylation and its links to human disease."xsd:string |
| http://purl.uniprot.org/citations/22948820 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms2041"xsd:string |
| http://purl.uniprot.org/citations/22948820 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms2041"xsd:string |
| http://purl.uniprot.org/citations/22948820 | http://purl.uniprot.org/core/author | "Falnes P.O."xsd:string |
| http://purl.uniprot.org/citations/22948820 | http://purl.uniprot.org/core/author | "Falnes P.O."xsd:string |
| http://purl.uniprot.org/citations/22948820 | http://purl.uniprot.org/core/author | "Moen A."xsd:string |
| http://purl.uniprot.org/citations/22948820 | http://purl.uniprot.org/core/author | "Moen A."xsd:string |
| http://purl.uniprot.org/citations/22948820 | http://purl.uniprot.org/core/author | "Egge-Jacobsen W."xsd:string |
| http://purl.uniprot.org/citations/22948820 | http://purl.uniprot.org/core/author | "Egge-Jacobsen W."xsd:string |
| http://purl.uniprot.org/citations/22948820 | http://purl.uniprot.org/core/author | "Kernstock S."xsd:string |
| http://purl.uniprot.org/citations/22948820 | http://purl.uniprot.org/core/author | "Kernstock S."xsd:string |
| http://purl.uniprot.org/citations/22948820 | http://purl.uniprot.org/core/author | "Davydova E."xsd:string |
| http://purl.uniprot.org/citations/22948820 | http://purl.uniprot.org/core/author | "Davydova E."xsd:string |
| http://purl.uniprot.org/citations/22948820 | http://purl.uniprot.org/core/author | "Jakobsson M."xsd:string |
| http://purl.uniprot.org/citations/22948820 | http://purl.uniprot.org/core/author | "Jakobsson M."xsd:string |
| http://purl.uniprot.org/citations/22948820 | http://purl.uniprot.org/core/author | "Maelandsmo G.M."xsd:string |
| http://purl.uniprot.org/citations/22948820 | http://purl.uniprot.org/core/author | "Maelandsmo G.M."xsd:string |
| http://purl.uniprot.org/citations/22948820 | http://purl.uniprot.org/core/author | "Pettersen S."xsd:string |
| http://purl.uniprot.org/citations/22948820 | http://purl.uniprot.org/core/author | "Pettersen S."xsd:string |
| http://purl.uniprot.org/citations/22948820 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22948820 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22948820 | http://purl.uniprot.org/core/name | "Nat. Commun."xsd:string |
| http://purl.uniprot.org/citations/22948820 | http://purl.uniprot.org/core/name | "Nat. Commun."xsd:string |