| http://purl.uniprot.org/citations/23029420 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23029420 | http://www.w3.org/2000/01/rdf-schema#comment | "Glioblastomas (GBMs) are the most common and lethal primary tumors of the central nervous system with high level of recurrence despite aggressive therapy. Tumor-associated proteins/peptides may appear in the plasma of these patients as a result of disruption of the blood-brain barrier in them, raising the scope for development of plasma-based tests for diagnosis and monitoring the disease. With this objective, we analyzed the levels of proteins present in the plasma from GBM patients using an iTRAQ based LC-MS/MS approach. Analysis with pooled plasma specimens from the patient and healthy control samples revealed high confidence identification of 296 proteins, of which 61 exhibited a fold-change ≥1.5 in the patient group. Forty-eight of them contained signal sequence. A majority have been reported in the differentially expressed transcript or protein profile of GBM tissues; 6 have been previously studied as plasma biomarkers for GBM and 16 for other types of cancers. Altered levels of three representative proteins-ferritin light chain (FTL), S100A9, and carnosinase 1 (CNDP1)-were verified by ELISA in a test set of ten individual plasma specimens. FTL is an inflammation marker also implicated in cancer, S100A9 is an important member of the Ca(2+) signaling cascade reported to be altered in GBM tissue, and CNDP1 has been reported for its role in the regulation of the levels of carnosine, implicated as a potential drug for GBM. These and other proteins in the dataset may form useful starting points for further clinical investigations for the development of plasma-based biomarker panels for GBM."xsd:string |
| http://purl.uniprot.org/citations/23029420 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0046153"xsd:string |
| http://purl.uniprot.org/citations/23029420 | http://purl.uniprot.org/core/author | "Harsha H.C."xsd:string |
| http://purl.uniprot.org/citations/23029420 | http://purl.uniprot.org/core/author | "Sharma R."xsd:string |
| http://purl.uniprot.org/citations/23029420 | http://purl.uniprot.org/core/author | "Gupta M.K."xsd:string |
| http://purl.uniprot.org/citations/23029420 | http://purl.uniprot.org/core/author | "Gautam P."xsd:string |
| http://purl.uniprot.org/citations/23029420 | http://purl.uniprot.org/core/author | "Sirdeshmukh R."xsd:string |
| http://purl.uniprot.org/citations/23029420 | http://purl.uniprot.org/core/author | "Chandak G.R."xsd:string |
| http://purl.uniprot.org/citations/23029420 | http://purl.uniprot.org/core/author | "Nair S.C."xsd:string |
| http://purl.uniprot.org/citations/23029420 | http://purl.uniprot.org/core/author | "Sundaram C."xsd:string |
| http://purl.uniprot.org/citations/23029420 | http://purl.uniprot.org/core/author | "Ankathi P."xsd:string |
| http://purl.uniprot.org/citations/23029420 | http://purl.uniprot.org/core/author | "Polisetty R.V."xsd:string |
| http://purl.uniprot.org/citations/23029420 | http://purl.uniprot.org/core/author | "Puligopu A.K."xsd:string |
| http://purl.uniprot.org/citations/23029420 | http://purl.uniprot.org/core/author | "Purohit A.K."xsd:string |
| http://purl.uniprot.org/citations/23029420 | http://purl.uniprot.org/core/author | "Uppin M.S."xsd:string |
| http://purl.uniprot.org/citations/23029420 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23029420 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/23029420 | http://purl.uniprot.org/core/pages | "e46153"xsd:string |
| http://purl.uniprot.org/citations/23029420 | http://purl.uniprot.org/core/title | "Proteins with altered levels in plasma from glioblastoma patients as revealed by iTRAQ-based quantitative proteomic analysis."xsd:string |
| http://purl.uniprot.org/citations/23029420 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/23029420 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23029420 |
| http://purl.uniprot.org/citations/23029420 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23029420 |
| http://purl.uniprot.org/uniprot/#_A0A384MDR3-mappedCitation-23029420 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23029420 |
| http://purl.uniprot.org/uniprot/#_A8K1K1-mappedCitation-23029420 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23029420 |