| http://purl.uniprot.org/citations/23077300 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23077300 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23077300 | http://www.w3.org/2000/01/rdf-schema#comment | "Members of the tripartite interaction motif (TRIM) family of E3 ligases are emerging as critical regulators of innate immunity. To identify new regulators, we carried out a screen of 43 human TRIM proteins for the ability to activate NF-κB, AP-1, and interferon, hallmarks of many innate immune signaling pathways. We identified 16 TRIM proteins that induced NF-κB and/or AP-1. We found that one of these, TRIM62, functions in the TRIF branch of the TLR4 signaling pathway. Knockdown of TRIM62 in primary macrophages led to a defect in TRIF-mediated late NF-κB, AP-1, and interferon production after lipopolysaccharide challenge. We also discovered a role for TRIM15 in the RIG-I-mediated interferon pathway upstream of MAVS. Knockdown of TRIM15 limited virus/RIG-I ligand-induced interferon production and enhanced vesicular stomatitis virus replication. In addition, most TRIM proteins previously identified to inhibit murine leukemia virus (MLV) demonstrated an ability to induce NF-κB/AP-1. Interfering with the NF-κB and AP-1 signaling induced by the antiretroviral TRIM1 and TRIM62 proteins rescued MLV release. In contrast, human immunodeficiency virus type 1 (HIV-1) gene expression was increased by TRIM proteins that induce NF-κB. HIV-1 resistance to inflammatory TRIM proteins mapped to the NF-κB sites in the HIV-1 long terminal repeat (LTR) U3 and could be transferred to MLV. Thus, our work identifies new TRIM proteins involved in innate immune signaling and reinforces the striking ability of HIV-1 to exploit innate immune signaling for the purpose of viral replication."xsd:string |
| http://purl.uniprot.org/citations/23077300 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.01804-12"xsd:string |
| http://purl.uniprot.org/citations/23077300 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.01804-12"xsd:string |
| http://purl.uniprot.org/citations/23077300 | http://purl.uniprot.org/core/author | "Hinz A."xsd:string |
| http://purl.uniprot.org/citations/23077300 | http://purl.uniprot.org/core/author | "Hinz A."xsd:string |
| http://purl.uniprot.org/citations/23077300 | http://purl.uniprot.org/core/author | "Mothes W."xsd:string |
| http://purl.uniprot.org/citations/23077300 | http://purl.uniprot.org/core/author | "Mothes W."xsd:string |
| http://purl.uniprot.org/citations/23077300 | http://purl.uniprot.org/core/author | "Luban J."xsd:string |
| http://purl.uniprot.org/citations/23077300 | http://purl.uniprot.org/core/author | "Luban J."xsd:string |
| http://purl.uniprot.org/citations/23077300 | http://purl.uniprot.org/core/author | "Uchil P.D."xsd:string |
| http://purl.uniprot.org/citations/23077300 | http://purl.uniprot.org/core/author | "Uchil P.D."xsd:string |
| http://purl.uniprot.org/citations/23077300 | http://purl.uniprot.org/core/author | "Pertel T."xsd:string |
| http://purl.uniprot.org/citations/23077300 | http://purl.uniprot.org/core/author | "Pertel T."xsd:string |
| http://purl.uniprot.org/citations/23077300 | http://purl.uniprot.org/core/author | "Coenen-Stass A."xsd:string |
| http://purl.uniprot.org/citations/23077300 | http://purl.uniprot.org/core/author | "Coenen-Stass A."xsd:string |
| http://purl.uniprot.org/citations/23077300 | http://purl.uniprot.org/core/author | "Siegel S."xsd:string |
| http://purl.uniprot.org/citations/23077300 | http://purl.uniprot.org/core/author | "Siegel S."xsd:string |
| http://purl.uniprot.org/citations/23077300 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23077300 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23077300 | http://purl.uniprot.org/core/name | "J. Virol."xsd:string |
| http://purl.uniprot.org/citations/23077300 | http://purl.uniprot.org/core/name | "J. Virol."xsd:string |
| http://purl.uniprot.org/citations/23077300 | http://purl.uniprot.org/core/pages | "257-272"xsd:string |
| http://purl.uniprot.org/citations/23077300 | http://purl.uniprot.org/core/pages | "257-272"xsd:string |