| http://purl.uniprot.org/citations/23084835 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23084835 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23084835 | http://www.w3.org/2000/01/rdf-schema#comment | "The Male-Specific Lethal (MSL) complex regulates dosage compensation of the male X chromosome in Drosophila. Here, we report the crystal structure of its MSL1/MSL2 core, where two MSL2 subunits bind to a dimer formed by two molecules of MSL1. Analysis of structure-based mutants revealed that MSL2 can only interact with the MSL1 dimer, but MSL1 dimerization is MSL2 independent. We show that Msl1 is a substrate for Msl2 E3 ubiquitin ligase activity. ChIP experiments revealed that Msl1 dimerization is essential for targeting and spreading of the MSL complex on X-linked genes; however, Msl1 binding to promoters of male and female cells is independent of the dimer status and other MSL proteins. Finally, we show that loss of Msl1 dimerization leads to male-specific lethality. We propose that Msl1-mediated dimerization of the entire MSL complex is required for Msl2 binding, X chromosome recognition, and spreading along the X chromosome."xsd:string |
| http://purl.uniprot.org/citations/23084835 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2012.09.014"xsd:string |
| http://purl.uniprot.org/citations/23084835 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2012.09.014"xsd:string |
| http://purl.uniprot.org/citations/23084835 | http://purl.uniprot.org/core/author | "Cusack S."xsd:string |
| http://purl.uniprot.org/citations/23084835 | http://purl.uniprot.org/core/author | "Cusack S."xsd:string |
| http://purl.uniprot.org/citations/23084835 | http://purl.uniprot.org/core/author | "Kadlec J."xsd:string |
| http://purl.uniprot.org/citations/23084835 | http://purl.uniprot.org/core/author | "Kadlec J."xsd:string |
| http://purl.uniprot.org/citations/23084835 | http://purl.uniprot.org/core/author | "Akhtar A."xsd:string |
| http://purl.uniprot.org/citations/23084835 | http://purl.uniprot.org/core/author | "Akhtar A."xsd:string |
| http://purl.uniprot.org/citations/23084835 | http://purl.uniprot.org/core/author | "Lipp M."xsd:string |
| http://purl.uniprot.org/citations/23084835 | http://purl.uniprot.org/core/author | "Lipp M."xsd:string |
| http://purl.uniprot.org/citations/23084835 | http://purl.uniprot.org/core/author | "Georgiev P."xsd:string |
| http://purl.uniprot.org/citations/23084835 | http://purl.uniprot.org/core/author | "Georgiev P."xsd:string |
| http://purl.uniprot.org/citations/23084835 | http://purl.uniprot.org/core/author | "Hallacli E."xsd:string |
| http://purl.uniprot.org/citations/23084835 | http://purl.uniprot.org/core/author | "Hallacli E."xsd:string |
| http://purl.uniprot.org/citations/23084835 | http://purl.uniprot.org/core/author | "Spielman C."xsd:string |
| http://purl.uniprot.org/citations/23084835 | http://purl.uniprot.org/core/author | "Spielman C."xsd:string |
| http://purl.uniprot.org/citations/23084835 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23084835 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/23084835 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/23084835 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/23084835 | http://purl.uniprot.org/core/pages | "587-600"xsd:string |
| http://purl.uniprot.org/citations/23084835 | http://purl.uniprot.org/core/pages | "587-600"xsd:string |